多烯磷脂酰胆碱改善肝功能异常相关的凝血功能障碍的疗效研究  

Study on the Therapeutic Effect of Polyene Phosphatidylcholine in Improving Coagulation Dysfunction Related to Liver Dysfunction

作　　者：黎伟政 叶秀银 邓颖[1] 吴平[1] 杨文晓[1] 张小娟 任伟旺[1] LI Weizheng;YE Xiuyin;DENG Ying;WU Ping;YANG Wenxiao;ZHANG Xiaojuan;REN Weiwang(Department of Gastroenterology,Maoming People′s Hospital,Maoming Guangdong 525000,China)

机构地区：[1]茂名市人民医院消化内科,广东茂名525000

出　　处：《中国卫生标准管理》2025年第2期118-121,共4页China Health Standard Management

基　　金：广东省医学科学技术研究基金项目(B2021464)。

摘　　要：目的 探讨多烯磷脂酰胆碱改善肝功能异常相关的凝血功能障碍的疗效。方法 选择2021年7月—2023年6月茂名市人民医院接诊的肝功能异常相关的凝血功能障碍患者66例为研究对象,采用奇偶分组的方式将66例患者分为对照组和观察组,各33例。对照组应用丁二磺酸腺苷蛋氨酸注射液、异甘草酸镁注射液、熊去氧胆酸、甘草酸二铵实施治疗,观察组采用丁二磺酸腺苷蛋氨酸注射液、多烯磷脂酰胆碱注射液、熊去氧胆酸、多烯磷脂酰胆碱胶囊治疗。比较2组的肝功能指标(血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血清总胆红素)及凝血功能指标[凝血酶原时间活动度(prothrombin time activity,PTA)、凝血酶原时间(prothrombin tim,PT)、国际标准化比值(International normalized ratio,INR)]。结果 观察组血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血清总胆红素分别为(48.76±4.98)IU/L、(38.76±3.05)IU/L、(42.63±5.73)μmol/L,均优于对照组的(33.81±5.62)IU/L、(27.37±8.04)IU/L、(51.73±6.82)μmol/L,差异有统计学意义(P <0.05)。观察组的PTA、PT、INR指标分别为(39.61±11.83)%、(19.92±5.04)s、(1.63±0.32),均优于对照组的(33.35±12.97)%、(24.72±8.01)s、(2.12±0.68),差异有统计学意义(P <0.05)。结论 多烯磷脂酰胆碱改善肝功能异常相关的凝血功能障碍的疗效显著,不仅能促进患者血清总胆红素指标改善,也能促进患者凝血功能有关指标完善,但是在促进患者血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶改善的方面,异甘草酸镁具有更好的效果。Objective To explore the therapeutic effect of polyene phosphatidylcholine in improving coagulation dysfunction related to liver dysfunction.Methods A total of 66 patients with coagulation disorders related to abnormal liver function who were treated at Maoming People′s Hospital from July 2021 to June 2023 were selected as subjects.The patients were divided into a control group and an observation group,each consisting of 33 patients,using an odd-even grouping method.The control group was treated with adenosylmethionine disulfonate injection,magnesium isoglycyrrhizinate injection,ursodeoxycholic acid,and diammonium glycyrrhizinate,while the observation group received adenosylmethionine disulfonate injection,polyene phosphatidylcholine injection,ursodeoxycholic acid,and polyene phosphatidylcholine capsules.The liver function indicators(serum alanine aminotransferase,aspartate aminotransferase,total serum bilirubin)and coagulation function indicators[prothrombin time activity(PTA),prothrombin time(PT),international normalized ratio(INR)]of the two groups were compared.Results The serum alanine aminotransferase,aspartate aminotransferase,and total serum bilirubin levels in the observation group were(48.76±4.98)IU/L,(38.76±3.05)IU/L and(42.63±5.73)μmol/L,respectively,all of which were better than those in the control group at(33.81±5.62)IU/L,(27.37±8.04)IU/L,and(51.73±6.82)μmol/L,with statistically significant differences(P<0.05).The PTA,PT,and INR indicators in the observation group were(39.61±11.83)%,(19.92±5.04)s,and(1.63±0.32),respectively,all of which were better than those in the control group at(33.35±12.97)%,(24.72±8.01)s,and(2.12±0.68),with statistically significant differences(P<0.05).Conclusion Polyene phosphatidylcholine has a significant therapeutic effect on improving coagulation dysfunction related to liver dysfunction.It can not only promote the improvement of serum total bilirubin indicators in patients,but also improve coagulation function related indicators.However,magnesium isoglycy

关 键 词：多烯磷脂酰胆碱 改善 肝功能异常 凝血功能障碍 疗效 探索性研究 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]