益母草注射液联合西药治疗产后宫缩乏力性出血的临床研究  

Clinical Study on the Combination of Yimu Cao Injection and Western Medicine in the Treatment of Postpartum Uterine Atony and Hemorrhage

作　　者：王莹 纪智荣 周晓光[1] WANG Ying;JI Zhirong;ZHOU Xiaoguang(Department of Obstetrics,Chifeng Municipal Hospital,Chifeng Inner Mongolia 024000,China)

机构地区：[1]赤峰市医院产科,内蒙古赤峰024000

出　　处：《中国卫生标准管理》2025年第2期137-140,共4页China Health Standard Management

摘　　要：目的探讨产后宫缩乏力性出血患者采用益母草注射液联合西药治疗的临床效果。方法选择2023年1月—2024年1月在赤峰市医院产科分娩后出现产后宫缩乏力性出血的86例患者,按随机双盲法分为研究组(益母草注射液联合缩宫素、米索前列醇治疗)与对照组(缩宫素+米索前列醇治疗),各43例。比较2组的临床疗效、产后2、12、24 h出血量,并测定卵巢功能指标[雌二醇(estradiol,E2)、促卵泡生成素(follicle stimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)]、凝血功能指标[凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)]等指标变化。结果治疗后,研究组总有效率(95.35%)高于对照组(79.07%),差异有统计学意义(P<0.05)。治疗后,研究组产后2、12、24 h出血量为(172.56±21.39)mL、(201.40±23.62)mL、(247.58±26.24)mL,低于对照组的(218.74±25.93)mL、(271.05±29.15)mL、(315.79±31.33)mL,差异均有统计学意义(P<0.05)。治疗后,2组卵巢功能指标血清E2均提高,研究组为(28.59±5.48)pmol/mL,高于对照组的(24.04±4.20)pmol/mL,差异有统计学意义(P<0.05);2组血清LH、FSH水平均降低,研究组为(2.95±0.42)U/L、(3.60±0.75)U/L,低于对照组的(3.54±0.61)U/L、(4.32±0.83)U/L,差异有统计学意义(P<0.05)。治疗后,2组凝血功能指标FIB水平均提高,研究组为(28.50±4.12)g/L,高于对照组的(26.04±3.20)g/L,差异有统计学意义(P<0.05);2组PT、APTT均降低,研究组为(11.08±1.84)s、(30.02±3.34)s,低于对照组的(12.97±1.91)s、(34.26±3.59)s,差异有统计学意义(P<0.05)。结论产后宫缩乏力性出血患者给予益母草注射液联合西药的治疗效果显著,可有效调控凝血因子,减少产后出血量,并有助于改善患者卵巢功能。Objective To explore the clinical effect of using Yimu Cao injection combined with Western medicine to treat postpartum uterine atony and hemorrhage patients.Methods A total of 86 patients who experienced postpartum uterine atony and bleeding after giving birth at the obstetrics department of Chifeng Municipal Hospital from January 2023 to January 2024 were randomly divided into a study group(treated with motherwort injection combined with oxytocin and misoprostol)and a control group(treated with oxytocin and misoprostol)using a doubleblind method,with 43 cases in each group.The clinical efficacy,postpartum bleeding at 2,12,and 24 hours between two groups,and measure the changes in ovarian function indicators[estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH)],coagulation function indicators[prothrombin time(PT),fibrinogen(FIB),and activated partial thromboplastin time(APTT)]were compared.Results After treatment,the total effective rate of the study group(95.35%)was higher than that of the control group(79.07%),and the difference was statistically significant(P<0.05).After treatment,the postpartum bleeding volume of the study group at 2,12,and 24 hours was(172.56±21.39)mL,(201.40±23.62)mL,and(247.58±26.24)mL,which were lower than(218.74±25.93)mL,(271.05±29.15)mL,and(315.79±31.33)mL of the control group,and the differences were statistically significant(P<0.05).After treatment,both groups of ovarian function indicators showed an increase in serum E2,with the study group at(28.59±5.48)pmol/mL,which was higher than(24.04±4.20)pmol/mL of the control group,and the difference was statistically significant(P<0.05).The serum LH and FSH levels in both groups decreased,with the study group showing(2.95±0.42)U/L and(3.60±0.75)U/L,which were lower than(3.54±0.61)U/L and(4.32±0.83)U/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the FIB level,a coagulation function indicator,increased in both groups,the study group had a level of(28.50±4.12)g/L

关 键 词：宫缩乏力性出血 益母草注射液 缩宫素 米索前列醇 凝血功能 卵巢功能 

分 类 号：R511[医药卫生—内科学]