那屈肝素钙注射液在急性下肢深静脉血栓治疗中的有效性及安全性  

Efficacy and Safety of Nadroparin Calcium Injection in the Treatment of Acute Lower Extremity Deep Venous Thrombosis

作　　者：欧阳婷 OUYANG Ting(Pharmacy Department of Jiangxi Provincial People's Hospital Jinxian Hospital,Jinxian 331700,Jiangxi,China)

机构地区：[1]江西省人民医院进贤医院药剂科,江西进贤331700

出　　处：《医学信息》2025年第4期120-123,共4页Journal of Medical Information

摘　　要：目的研究那屈肝素钙注射液在急性下肢深静脉血栓治疗中的应用疗效及安全性。方法选取2020年1月-2023年12月江西省人民医院进贤医院收治的58例急性下肢深静脉血栓患者,经随机数字表法分为对照组(29例)和观察组(29例)。对照组行常规溶栓治疗,观察组在其基础上联合那屈肝素钙注射液治疗,比较两组临床疗效、凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、患肢肿胀程度(大腿周径差、小腿周径差)、并发症发生情况。结果观察组血管再通率高于对照组(P<0.05);两组治疗后PT、APTT指标大于治疗前,且观察组PT、APTT指标大于对照组(P<0.05);两组治疗后大腿周径差、小腿周径差均小于治疗前,且观察组大腿周径差、小腿周径差小于对照组(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论那屈肝素钙注射液在急性下肢深静脉血栓治疗中具有确切疗效,可改善患者凝血功能,缓解其患肢肿胀,且具有良好安全性。Objective To study the efficacy and safety of nadroparin calcium injection in the treatment of acute deep venous thrombosis of lower limbs.Methods A total of 58 patients with acute deep venous thrombosis of lower limbs admitted to the Jiangxi Provincial People's Hospital Jinxian Hospital from January 2020 to December 2023 were selected and divided into control group(29 patients)and observation group(29 patients)by random number table method.The control group was treated with routine thrombolysis,and the observation group was treated with nadroparin calcium injection on the basis of the control group.The clinical efficacy,coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT)],swelling degree of affected limb(thigh circumference difference,calf circumference difference)and complications were compared between the two groups.Results The vascular recanalization rate of the observation group was higher than that of the control group(P<0.05).The PT and APTT indexes of the two groups after treatment were higher than those before treatment,and the PT and APTT indexes of the observation group were higher than those of the control group(P<0.05).After treatment,the thigh circumference difference and calf circumference difference of the two groups were smaller than those before treatment,and the thigh circumference difference and calf circumference difference of the observation group were smaller than those of the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Nadroparin calcium injection has definite curative effect in the treatment of acute deep venous thrombosis of lower limbs,which can improve the coagulation function of patients,relieve the swelling of affected limbs,and has good safety.

关 键 词：急性下肢深静脉血栓 那屈肝素钙注射液 凝血功能 下肢肿胀 

分 类 号：R543.6[医药卫生—心血管疾病]