血清KL-6表达对社区获得性肺炎严重程度的诊断价值  

Diagnostic Value of Serum KL-6 Expression in the Severity of Community-acquired Pneumonia

作　　者：徐仁沙 杨广民[2] XU Rensha;YANG Guangmin(School of Clinical Medicine,Changchun University of Traditional Chinese Medicine,Changchun 130000,Jilin,China;Department of Laboratory,Jilin Provincial People′s Hospital,Changchun 130000,Jilin,China)

机构地区：[1]长春中医药大学临床医学院,吉林长春130000 [2]吉林省人民医院检验科,吉林长春130000

出　　处：《医学信息》2025年第4期124-127,共4页Journal of Medical Information

摘　　要：目的探究血清涎液化糖链抗原(KL-6)表达对社区获得性肺炎(CAP)严重程度的预测价值。方法选取2022年3月-4月收住在吉林省人民医院的CAP成人患者128例(重症组18例,非重症组110例)。另选性别、年龄与之相匹配的健康体检者128例(健康对照组)。检测并对比三组血清KL-6水平,分析血清KL-6表达与CAP严重程度的关系,采用受试者工作特征曲线(ROC曲线)分析血清KL-6水平对重症CAP的预测价值观察血清KL-6水平作为鉴别重症与非重症的敏感性及特异性。结果重症组合并肝脏疾病、肾脏疾病、电解质紊乱、脑梗的合并率高于非重症组,差异有统计学意义(P<0.05),而两者合并高血压、糖尿病、心脏病占比比较,差异无统计学意义(P>0.05)。重症组血清KL-6水平高于非重症组、健康对照组,非重症患者组血清KL-6水平高于健康对照组(P<0.05)。ROC分析可知,曲线下面积(AUC)为92.20%,95%CI(0.920,0.924),P=0.000,最佳临界值为439 U/ml,敏感性为99.00%,特异性为82.10%。结论血清KL-6水平与CAP严重程度有关,对早期预测重症CAP具有重要的参考价值,值得临床应用。Objective To explore the predictive value of Krebs von den Lungen 6(KL-6)expression for the severity of community-acquired pneumonia(CAP).Methods A total of 128 adult patients with CAP(18 patients in the severe group and 110 patients in the non-severe group)admitted to Jilin Provincial People's Hospital from March to April 2022 were selected.Another 128 healthy subjects(healthy control group)with matching gender and age were selected.The serum KL-6 levels of the three groups were detected and compared,and the relationship between serum KL-6 expression and the severity of CAP was analyzed.The receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of serum KL-6 level for severe CAP.The sensitivity and specificity of serum KL-6 level as a differential diagnosis of severe and non-severe.Results The combined rate of severe group with liver disease,kidney disease,electrolyte disorder and cerebral infarction was higher than that of non-severe group,and the difference was statistically significant(P<0.05),while there was no significant difference in the proportion of hypertension,diabetes,heart disease between the two groups(P>0.05).The serum KL-6 level in severe group was higher than that in non-severe group and healthy control group,and the serum KL-6 level in non-severe group was higher than that in healthy control group(P<0.05).ROC analysis showed that the area under the curve(AUC)was 92.20%,and the 95%CI was(0.920,0.924),P=0.000.The optimal critical value was 439 U/ml,the sensitivity was 99.00%,and the specificity was 82.10%.Conclusion Serum KL-6 level is related to the severity of CAP,which has important reference value for early prediction of severe CAP and is worthy of clinical application.

关 键 词：血清KL-6 社区获得性肺炎 重症 

分 类 号：R563.1[医药卫生—呼吸系统]