益肾固本膏方联合金匮肾气丸治疗肾虚型支气管哮喘缓解期患者的临床观察  

Clinical Observation of Yishen Guben Ointment Combined with Jinkui Shenqi Pill in the Treatment of Patients with Bronchial Asthma in Remission Stage of Kidney Deficiency Type

作　　者：龚珍 GONG Zhen(Department of Internal Medicine,Anyi County Hospital of Traditional Chinese Medicine,Anyi 330500,Jiangxi,China)

机构地区：[1]安义县中医院内科,江西安义330500

出　　处：《医学信息》2025年第4期140-143,共4页Journal of Medical Information

摘　　要：目的研讨益肾固本膏方联合金匮肾气丸治疗肾虚型支气管哮喘缓解期患者的效果。方法选取安义县中医院2021年1月-2023年12月收治的40例肾虚型支气管哮喘缓解期患者为研究对象,采用随机数字表法将其分成对照组和研究组,每组20例。对照组采用金匮肾气丸治疗,研究组在对照组基础上应用益肾固本膏方治疗。比较两组治疗总有效率、症状缓解时间(哮鸣音、咳嗽、肺部湿罗音、胸闷)、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、峰值呼气流速(PEF)]、血清炎性因子水平[肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-8(IL-8)]、中医证候(胸膈满闷、咳痰、咳嗽)积分。结果研究组治疗总有效率高于对照组(P<0.05)。研究组症状缓解时间均短于对照组(P<0.05)。两组治疗后肺功能指标水平均高于治疗前,且研究组肺功能指标水平高于对照组(P<0.05)。两组治疗后炎性因子水平均低于治疗前,且研究组炎性因子水平均低于对照组(P<0.05)。两组治疗后中医症候积分均低于治疗前,且研究组中医证候积分均低于对照组(P<0.05)。结论益肾固本膏方联合金匮肾气丸治疗肾虚型支气管哮喘缓解期患者的效果确切,可以快速缓解患者症状,改善肺功能,降低血清炎性因子水平。Objective To study the effect of Yishen Guben ointment combined with Jinkui Shenqi pill in the treatment of patients with bronchial asthma in remission stage of kidney deficiency type.Methods A total of 40 patients with bronchial asthma of kidney deficiency type admitted to Anyi County Hospital of Traditional Chinese Medicine from January 2021 to December 2023 were selected as the research objects.They were divided into control group and study group by random number table method,with 20 patients in each group.The control group was treated with Jinkui Shenqi pills,and the study group was treated with Yishen Guben ointment on the basis of the control group.The total effective rate of treatment,symptom relief time(wheezing sound,cough,lung wet rale,chest tightness),lung function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow rate(PEF)],serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-8(IL-8)],TCM syndromes(chest and diaphragm fullness,sputum,cough)scores were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).The relief time of symptoms in the study group was shorter than that in the control group(P<0.05).The levels of lung function indexes in the two groups after treatment were higher than those before treatment,and the levels of lung function indexes in the study group were higher than those in the control group(P<0.05).The levels of inflammatory factors in the two groups after treatment were lower than those before treatment,and the levels of inflammatory factors in the study group were lower than those in the control group(P<0.05).The scores of TCM syndromes in the two groups after treatment were lower than those before treatment,and the scores of TCM syndromes in the study group were lower than those in the control group(P<0.05).Conclusion Yishen Guben ointment combined with Jinkui Shenqi pill is effective in the treatment

关 键 词：益肾固本膏方 金匮肾气丸 肾虚型支气管哮喘 

分 类 号：R256.12[医药卫生—中医内科学]