基于数据挖掘分析中药膏方治疗虚劳用药规律  

Medication Rules of Chinese Medicinal Paste Prescriptions for Treating Consumptive Disease Based on Data Mining

作　　者：陈燕霞 邓广海 朱晨 龚又明 CHEN Yanxia;DENG Guanghai;ZHU Chen;GONG Youming(Department of Pharmacy,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510120,China)

机构地区：[1]广州中医药大学第二附属医院药学部,广东广州510120

出　　处：《新中医》2025年第5期1-6,共6页New Chinese Medicine

基　　金：广东省中医药局科研项目(20222068)。

摘　　要：目的:采用数据挖掘方法分析中药膏方治疗虚劳的用药规律。方法:收集2018年12月—2021年12月广州中医药大学第二附属医院门诊有关治疗虚劳的中药膏方医案,根据纳入、排除标准对膏方医案进行数据提取、整理,采用古今医案云平台分析患者信息、中药频次、性味归经、关联规则和复杂网络等,总结中药膏方治疗虚劳的用药规律。结果:共纳入336首处方,涉及中药321味。虚劳主要中医证型有阴阳两虚证、肝肾不足证、气血不足证、肾气不足证等。膏方治疗虚劳的高频中药有人参、茯苓、陈皮、炙甘草等,中药药性以温、平性为主,药味以甘、辛味多见,多归于脾、肺、肾、肝经。膏方常见药物组合有柴胡-人参、陈皮-茯苓、炙甘草-人参、当归-人参等。聚类分析得到砂仁-菟丝子、川芎-枳壳-白术-当归-黄芪-山茱萸-熟地黄-山药、白芍-法半夏-柴胡-黄芩-桂枝-大枣-人参-茯苓-陈皮-炙甘草3个聚类方。复杂网络分析得到茯苓-人参-陈皮-炙甘草-熟地黄-柴胡-当归-桂枝-砂仁-黄芩-山药-白芍-白术-大枣核心组合。结论:中医药治疗虚劳以补气生血、益阴和阳为主要治法,常以四君子汤、四物汤和柴胡桂枝汤为基础方加减治疗。Objective:To analyze the medication rules of Chinese medicinal paste prescriptions for treating consumptive disease based on data mining.Methods:Chinese medicinal paste prescriptions related to the treatment of consumptive disease in the outpatient department of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from December 2018 to December 2021 were collected.The data of paste prescriptions were extracted and organized according to inclusion and exclusion criteria.The Ancient and Modern Medical Case Cloud Platform was used to analyze patient information,frequency of Chinese medicinals,the nature,flavors,and meridian entries of Chinese medicinals,association rules,and complex networks;the medication rules of Chinese medicinal paste prescriptions for the treatment of consumptive disease were summarized.Results:A total of 336 prescriptions were included,involving 321 Chinese medicinals.The main traditional Chinese medicine syndromes of the consumptive disease included yin-yang deficiency syndrome,the liver-kidney insufficiency syndrome,qi-blood deficiency syndrome,and the kidney qi insufficiency syndrome.The high-frequency Chinese medicinals used in the treatment of the consumptive disease with paste prescriptions included Ginseng Radix et Rhizoma,Poria,Citri Reticulatae Pericarpium,and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle;the nature of Chinese medicinals were mainly warm and neutral,with the main flavors were sweet and acrid;the major meridian entries were the spleen,lung,kidney,and liver meridians.Common herbal combinations of paste prescriptions included Bupleuri Radix-Ginseng Radix et Rhizoma,Citri Reticulatae Pericarpium-Poria,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle-Ginseng Radix et Rhizoma,and Angelicae Sinensis Radix-Ginseng Radix et Rhizoma.Three cluster prescriptions were obtained by cluster analysis,namely Amomi Fructus-Cuscutae Semen,Chuanxiong Rhizoma-Aurantii Fructus-Atractylodis Macrocephalae Rhizoma-Angelicae Sinensis Radix-Astragali Radix-Corni Fruc

关 键 词：虚劳 中药膏方 数据挖掘 用药规律 

分 类 号：R255.5[医药卫生—中医内科学]