人参灵芝鱼胶液治疗肿瘤相关性厌食临床研究  

Clinical Study on Renshen Lingzhi Yujiao Liquid for Anorexia Related with Tumor

作　　者：吴泽霞 常雪松 刘译鸿[2] 张海波[2] 朱燕娟[2] 何怡瀚[2] 余娅娅 肖真真 陈亚栋 WU Zexia;CHANG Xuesong;LIU Yihong;ZHANG Haibo;ZHU Yanjuan;HE Yihan;YU Yaya;XIAO Zhenzhen;CHEN Yadong(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;Guangdong Provincial Hospital of Chinese Medicine,Guangzhou Guangdong 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510405 [2]广东省中医院,广东广州510120

出　　处：《新中医》2025年第5期136-140,共5页New Chinese Medicine

基　　金：粤港澳中医药与免疫疾病研究联合实验室(2020B1212030006);广州地区中西医协同临床重大创新技术建设项目(穗卫函〔2023〕2318号)。

摘　　要：目的:观察人参灵芝鱼胶液治疗肿瘤相关性厌食的临床疗效。方法:选取2020年12月-2021年12月广东省中医院收治的接受化疗或化疗联合靶向治疗的45例肿瘤相关性厌食患者,按随机数字表法分为中药组、西药组、对照组各15例。治疗过程中西药组脱落5例,最终中药组、对照组各15例,西药组10例。中药组口服人参灵芝鱼胶液治疗,西药组口服醋酸甲地孕酮分散片治疗,对照组不予干预措施。3组均治疗6周。观察3组不良反应发生情况,比较3组治疗前后食欲视觉模拟评分法(VAS)评分、埃德蒙顿症状评估量表(ESAS)评分、血红蛋白、白细胞、血小板等实验室检查指标值的变化。结果:中药组食欲VAS评分治疗6周后与治疗前比较,差异有统计学意义(P<0.05)。3组治疗前、治疗6周后的食欲VAS评分比较,差异均无统计学意义(P>0.05)。ESAS评分组内及组间比较,差异均无统计学意义(P>0.05);血红蛋白、白细胞治疗前后差值组间比较,差异均有统计学意义(P<0.05)。治疗6周后,中药组血红蛋白差值高于西药组(P<0.05),对照组血红蛋白差值高于西药组(P<0.05);中药组白细胞差值高于对照组(P<0.05)。在抗肿瘤治疗相关不良反应方面,无3、4级不良反应发生(P>0.05)。结论:人参灵芝鱼胶液能够改善肿瘤相关性厌食症状,提升免疫力,有改善骨髓抑制的作用。Objective:To observe the clinical effect of Renshen Lingzhi Yujiao Liquid for anorexia related with tumor.Methods:A total of 45 patients with anorexia related with tumor who received chemotherapy or chemotherapy combined with targeted therapy at Guangdong Provincial Hospital of Chinese Medicine from December 2020 to December 2021 were selected and divided into the Chinese medicine group,the western medicine group,and the control group,with 15 patients in each group according to random number table method.During the treatment process,five cases were dropped from the western medicine group,ultimately with 15 cases in the Chinese medicine group and 15 cases in the control group,and 10 cases in the western medicine group.The Chinese medicine group was orally treated with Renshen Lingzhi Yujiao Liquid,and the western medicine group was treated with oral administration of Medroxyprogesterone Acetate Dispersible Tablets.The control group did not receive any intervention measures.All three groups were treated for six weeks.Observed the occurrence of adverse reactions in three groups and compared the changes in Visual Analogue Scale(VAS)of appetite,Edmonton Symptom Assessment Scale(ESAS)scores,hemoglobin,white blood cells,platelets and other laboratory test indicators before and after treatment in the three groups.Results:There was significant difference in the comparison of the VAS scores of appetite after six weeks of treatment and before treatment in the Chinese medicine group(P<0.05).while no statistically significant differences were presented in the comparison of the VAS scores of appetite before treatment and after six weeks of treatment among the three groups(P>0.05).There was no significant difference in the intra group and inter group comparisons of ESAS scores(P>0.05);however,the difference in hemoglobin and white blood cell levels before and after treatment showed significance when compared among the three groups(P<0.05).After six weeks of treatment,the difference between the hemoglobin level of the Chinese me

关 键 词：肿瘤相关性厌食 人参灵芝鱼胶液 醋酸甲地孕酮 埃德蒙顿症状评估量表 

分 类 号：R273[医药卫生—中西医结合]