维生素D及其受体基因多态性与骨结核易感性的研究进展  

Research progress on polymorphism of vitamin D and its receptor gene and susceptibility to bone tuberculosis

作　　者：刘鑫锋 张彦军[2] 李军杰 杨军 田宏晶 LIU Xin-feng;ZHANG Yan-jun;LI Jun-jie;YANG Jun;TIAN Hong-jing(Gansu University of Chinese Mdicine,Lanzhou 730000,Gansu,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国骨伤》2025年第2期211-216,共6页China Journal of Orthopaedics and Traumatology

基　　金：2021年甘肃省财政转移支付地方项目(编号:20210140305);2023年甘肃省卫生行业项目(编号:GSWSKY2023-27);2022年甘肃省科技计划项目(编号:22JR5RA624);2016年兰州市科技计划项目(编号:2016-3-114)。

摘　　要：骨结核作为肺外结核的主要病变部位之一,受累部位表现局部疼痛和活动受限,严重者面临较高的致畸和致残风险,尤其在耐多药结核日益蔓延的情境下,寻求创新的治疗方案显得尤为紧迫。近年来,维生素D在骨结核的预防和治疗中崭露头角,作用机制不断被挖掘,同时,维生素D受体基因多态性也被发现与骨结核的易感性和发病风险密切相关。本文综述了维生素D及其受体基因多态性与骨结核易感性之间的关系,发现无论是成年人或是儿童,缺乏维生素D均使得骨结核更加易感,维生素D受体多种基因型均对骨结核易感性有影响,其中FokⅠ基因型的影响更大,此外还发现健康人群大多也缺乏维生素D,可能也是导致骨结核病数量攀升的原因之一。通过对维生素D及其受体基因多态性与骨结核易感性之间的关系的研究,可以避免诱发骨结核的部分因素,更有针对性地进行相关新药的研发,如维生素D补充剂、基因受体相关拮抗剂等,为骨结核的预防和治疗提供更系统和有针对性的策略。Bone tuberculosis is one of the main lesions of extrapulmonary tuberculosis,and the affected site shows local pain and limited movement,and the severe patients face a higher risk of teratogenicity and disability.Especially in the context of the increasing spread of multidrug-resistant tuberculosis,it is particularly urgent to seek innovative treatment options.In recent years,vitamin D plays an important role in the prevention and treatment of bone tuberculosis,and the mechanism of action has been continuously explored.At the same time,vitamin D receptor gene polymorphism has also been found to be closely related to the susceptibility and risk of bone tuberculosis.This article reviewed the relationship between vitamin D and its receptor gene polymorphisms and the susceptibility to bone tuberculosis.It was found that vitamin D deficiency increased the susceptibility to bone tuberculosis in both adults and children,and multiple genotypes of vitamin D receptor had an effect on the susceptibility to bone tuberculosis,especially FokⅠgenotype.It may also be one of the reasons for the increase in the number of bone tuberculosis.Through the study of the relationship between vitamin D and its receptor gene polymorphism and the susceptibility to bone tuberculosis,some factors inducing bone tuberculosis can be avoided,and related new drugs can be more targeted,such as vitamin D supplements,gene receptor related antagonists,etc.To provide more systematic and targeted strategies for the prevention and treatment of bone tuberculosis.

关 键 词：骨结核 维生素D 维生素D受体 易感性 综述文献 

分 类 号：R529.2[医药卫生—内科学]