生物医用材料改性及其释放生物信号分子NO  

Modification of Biomedical Materials and Release of Biological Signal Molecule NO

作　　者：王宏 陈玉晶 陈晓贞 曲昌华 WANG Hong;CHEN Yujing;CHEN Xiaozhen;QU Changhua(Laboratory Department of Yantai Mountain Hospital,Yantai Shandong 264003,China;Sinopec(Dalian)Research Institute of Petroleum and Petrochemicals Co.,Ltd.,Dalian Liaoning 116045,China)

机构地区：[1]烟台市烟台山医院检验科,山东烟台264003 [2]中石化(大连)石油化工研究院有限公司,辽宁大连116045

出　　处：《当代化工》2025年第2期412-416,共5页Contemporary Chemical Industry

基　　金：国家自然科学基金项目(项目编号:21802118);高等教育科学研究规划课题项目(项目编号:23GR0220)。

摘　　要：单一的生物材料很难同时具备相容性好、无毒和柔韧性好等优点,为了使血液与材料具备良好的关系,因此需要对生物医用材料进行表面修饰。总结了目前表面修饰的方法,包括化学方法、物理方法、机械方法和生物方法。为了防止血管支架植入后发生血栓与再狭窄,需要在植入的生物材料附近分泌大量血管舒张和血管收缩因子NO,抑制血小板聚集引发凝血。总结了生物医用材料释放NO的2种主要方法,第一种是自释放策略,将产生NO的供体封装到材料表面,遇水释放出NO;第二种是催化生成策略,利用改性后的生物材料催化血液中的亚硝基硫醇实现NO的持续释放。It is difficult for a single biomaterial to simultaneously possess the advantages of good compatibility,nontoxicity,and good flexibility.In order to establish a good relationship between blood and the material,surface modification of biomedical materials is necessary.The current methods of surface modification were introduced,including chemical methods,physical methods,mechanical methods,and biological methods.In order to prevent thrombosis and restenosis after vascular stent implantation,it is necessary to secrete a large amount of vasodilator and vasoconstrictor factor NO near the implanted biomaterial to inhibit platelet aggregation and trigger coagulation.Two main methods for releasing NO from biomedical materials were summarized.The first strategy is the self-release strategy,which encapsulates the donor that produces NO onto the surface of the material and releases it upon contact with water;the second strategy is catalytic generation,which utilizes modified biomaterials to catalyze the continuous release of NO from nitrosothiol in the blood.

关 键 词：生物医用材料 改性 生物信号分子 NO 自催化 分子生物学 生物医学工程 

分 类 号：R446.1[医药卫生—诊断学] TQ033[医药卫生—临床医学]