Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis  

作　　者：Yizhi Zhang Xiao Chen Jing Dai Chenyun Wang Shan Ma Lina Du 

机构地区：[1]School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China [2]Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China [3]Information Department,General Hospital of Western War Zone,Chengdu 610083,China [4]Ministry of Health and Security,The Fourth Clinical Center Affiliated to Chinese PLA General Hospital,Beijing 100048,China [5]School of Rehabilitation Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2025年第1期79-85,共7页中医科学杂志(英文)

基　　金：supported by the Beijing Natural Science Foundation(L222126).

摘　　要：Objective:To observed the effect of a curcumin-based vaginal gel combined with electroporation for the treatment of vulvovaginal candidiasis(VVC)caused by Candida albicans.Methods:Temperature-sensitive in situ gels(ISG)were prepared using poloxamers 407 and 188 as matrices.The mass ratio of poloxamer 407 and poloxamer 188 was 7:1 with a gelation temperature of approximately 29℃ and gelation time of 2.5 min.Results:Electroporation increased the transmucosal permeability of the model drug,doxorubicin and improved the antifungal effects of curcumin.In vitro antifungal experiments showed that the number of fungal colonies in curcumin ISG combined with electroporation was lower than that in pure curcumin ISG.In vivo pharmacodynamic experiments showed that,compared to the model group,curcumin ISG with electroporation inhibited the growth of C.albicans,alleviated vaginal mucosal edema,and reduced the inflammatory response.Conclusion:Curcumin ISG combined with electroporation has substantial potential for the efficient clinical treatment of VVC.

关 键 词：ELECTROPORATION Vulvovaginal candidiasis Transmucosal delivery CURCUMIN In situ gels 

分 类 号：R711.31[医药卫生—妇产科学]