浙江省台州市海岛与山区中老年人群高尿酸血症患病率及影响因素研究  

Prevalence and associates of hyperuricemia in middle-and older-aged populations of islands and mountainous areas in Taizhou City of Zhejiang Province

作　　者：高艺航 王婷婷 陈泰霖 谢亚莉 王雅婷 汪剡灵 王良友[2] 林海江[2] 何纳 Gao Yihang;Wang Tingting;Chen Tailin;Xie Yali;Wang Yating;Wang Shanling;Wang Liangyou;Lin Haijiang;He Na(Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China;Zhejiang Taizhou City Center for Disease Control and Prevention,Taizhou 318000,China)

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]浙江省台州市疾病预防控制中心,台州318000

出　　处：《中华流行病学杂志》2025年第2期226-231,共6页Chinese Journal of Epidemiology

基　　金：台州市高层次人才特殊支持计划(TZ2022-2);上海市公共卫生体系建设三年行动计划(GWVI-11.1-05)。

摘　　要：目的掌握浙江省台州市海岛与山区中老年人群高尿酸血症(HUA)的患病率及主要影响因素。方法基于横断面研究,采取分层整群抽样及配额抽样的方法,整群抽样纳入椒江区海岛所有≥45岁的常住人口,在仙居县山区按年龄和性别匹配1∶1进行配额抽样,通过问卷调查和实验室检查收集其社会人口学特征、慢性病史、生活方式、体格和血生化指标等数据,通过logistic回归分析HUA与各因素之间的关联。结果共纳入研究对象971名,其中海岛468名,山区503名。HUA患病率为17.9%,其中海岛患病率(25.6%)高于山区(10.7%)。根据性别和年龄进行分层,在55~64岁男性、45~54岁女性、55~64岁女性和≥75岁女性中海岛和山区HUA患病率差异有统计学意义(均P<0.05)。多因素logistic回归分析显示,海产品摄入频率高(>3次/周)的研究对象有更高的HUA患病风险(OR=2.10,95%CI:1.33~3.34)。进一步以地区分层的多因素logistic回归分析显示,海岛研究人群中,男性(OR=3.15,95%CI:1.78~5.66)、中心性肥胖(OR=2.38,95%CI:1.46~3.93)、高TG血症(OR=2.00,95%CI:1.22~3.30)与HUA呈正相关(均P<0.05)。山区研究人群中,65~74岁年龄组(OR=3.50,95%CI:1.09~12.50)、男性(OR=6.79,95%CI:2.87~17.81)、企事业单位工作人员(OR=6.57,95%CI:1.92~23.73)和高血压(OR=3.68,95%CI:1.66~8.87)与HUA呈正相关(均P<0.05)。结论台州市海岛中老年人群的HUA患病率显著高于山区,应采取定期慢性病筛查、低脂饮食、减少海产品摄入和控制血压等针对性综合行为干预措施。Objective To determine the prevalence and associates of hyperuricemia(HUA)among the middle-and older-aged population of the island and mountainous areas in Taizhou City of Zhejiang Province.Methods A cross-sectional study was conducted on individuals aged 45 and above in the island and mountainous area of Taizhou City.The study included questionnaires,physical examinations,and laboratory tests.Data were primarily collected on sociodemographic characteristics,chronic disease history,lifestyle factors,waist circumference,blood pressure,and serum uric acid levels.The association between hyperuricemia and these factors was analyzed by logistic regression.Results A total of 971 individuals were included in the study,comprising 468 from island and 503 from mountainous area.The prevalence of hyperuricemia was 17.9%,with a significantly higher prevalence in the island area(25.6%)compared to the mountainous area(10.7%).Stratified by gender and age,differences in the prevalence of hyperuricemia between island and mountainous areas were observed in males aged 55 to 64,females aged 45 to 54,55 to 64,75 and above(all P<0.05).Multiple logistic regression analysis showed that high intake of sea food(>3 times/week)was positively associated with hyperuricemia(OR=2.10,95%CI:1.33-3.34).Furthermore,separate regionally stratified logistic regression analyses showed that in the island area,male gender(OR=3.15,95%CI:1.78-5.66),central obesity(OR=2.38,95%CI:1.46-3.93),and hypertriglyceridemia(OR=2.00,95%CI:1.22-3.30)were positively correlated with hyperuricemia(all P<0.05).In the mountainous area,the age group of 65 and above(OR=3.50,95%CI:1.09-12.50),male(OR=6.79,95%CI:2.87-17.81),those employed in enterprises and institutions(OR=6.57,95%CI:1.92-23.73)and hypertension(OR=3.68,95%CI:1.66-8.87)were positively correlated with hyperuricemia(all P<0.05).Conclusions The prevalence of hyperuricemia among the middle-and older-aged population in the island of Taizhou City is significantly higher than that in the mountainous areas.Targeted compr

关 键 词：高尿酸血症 中老年人群 海岛 山区 影响因素 

分 类 号：R589.7[医药卫生—内分泌]