河南省2023年HIV感染者常见慢性病患病情况及相关因素分析  

Prevalence of common chronic diseases and related factors in HIV-infected persons in Henan Province,2023

作　　者：陈昭云[1,2] 赵清霞 杨萱[1] 邓萌[1,2] 赵淑娴 刘春礼[1] 侯明杰[1] 张志会[1,2] 李琼 孙燕 Chen Zhaoyun;Zhao Qingxia;Yang Xuan;Deng Meng;Zhao Shuxian;Liu Chunli;Hou Mingjie;Zhang Zhihui;Li Qiong;Sun Yan(Henan Provincial Hospital of Infectious Diseases(The Sixth People's Hospital of Zhengzhou),Zhengzhou 450000,China;Office of Henan Provincial Clinical Research Center for Infectious Diseases(AIDS),Zhengzhou 450000,China)

机构地区：[1]河南省传染病医院(郑州市第六人民医院),郑州450000 [2]河南省传染病(艾滋病)临床医学研究中心,郑州450000

出　　处：《中华流行病学杂志》2025年第2期258-263,共6页Chinese Journal of Epidemiology

基　　金：河南省科技攻关项目(242102310204);郑州市医疗卫生领域科技创新指导计划(2024YLZDJH380);河南省传染病(艾滋病)临床医学研究中心开放课题(KFKT202411)。

摘　　要：目的分析2023年河南省HIV感染者常见慢性病(高脂血症、高血压和糖尿病)患病情况及相关因素。方法截至2023年12月,以河南省接受抗病毒治疗(ART)及随访年龄>15岁的HIV感染者为研究对象,开展问卷调查、体检和采集血样,收集研究对象的人口学信息、ART、体重、血脂、血压和血糖等资料。采用logistic回归模型分析高脂血症、高血压和糖尿病的相关因素。结果在HIV感染者4023例中,高脂血症、高血压和糖尿病患病率分别为64.47%(2594/4023)、16.80%(676/4023)、10.54%(424/4023)。多因素分析结果显示,高脂血症与≥40岁年龄组、超重和肥胖、使用2种核苷类反转录酶抑制剂(NRTIs)+蛋白酶抑制剂(PIs)治疗方案和2种NRTIs+整合酶抑制剂治疗方案呈正相关,与低体重呈负相关;高血压与≥40岁年龄组、心脑血管疾病家族史、超重和肥胖、ART时间≥0.5年呈正相关,与低体重呈负相关;糖尿病与≥40岁年龄组、心脑血管疾病家族史、超重和肥胖呈正相关,与使用2种NRTIs+PIs治疗方案呈负相关。结论2023年河南省HIV感染者高脂血症、高血压和糖尿病的患病率较高,≥40岁年龄组、超重和肥胖、有心脑血管疾病家族史者的常见慢性病的患病风险较高,建议加强HIV感染者常见慢性病的预防和管理。Objective To understand the prevalence and related factors of three common chronic diseases,hyperlipidemia,hypertension and diabetes in HIV-infected persons.Methods As of December 2023,HIV-infected persons>15 years old who are receiving antiviral therapy(ART)and follow-up in Henan Province were selected as the study objects.Questionnaires,physical examinations,and blood samples were collected to collect demographic information,ART,body weight,blood lipids,blood pressure,and blood sugar of HIV-infected persons.The logistic regression model was used to analyze the related factors of hyperlipidemia,hypertension and diabetes.Results Among 4023 HIV-infected patients,the prevalence rates of hyperlipidemia,hypertension,and diabetes were 64.47%(2594/4023),16.80%(676/4023),and 10.54%(424/4023),respectively.Multivariate analysis showed that hyperlipidemia was positively associated with≥40 years of age,overweight and obesity,two nucleoside reverse transcriptase inhibitors(NRTIs)+proteasome inhibitors(PIs)regimen and two NRTIs+integrase inhibitor regimen,and negatively associated with low body weight.Hypertension was positively correlated with the age group≥40 years old,family history of cardiovascular and cerebrovascular diseases,overweight and obesity,ART time≥0.5 years,and negatively correlated with low body weight.Diabetes was positively associated with age group≥40 years,family history of cardiovascular and cerebrovascular disease,overweight and obesity,and negatively associated with the use of two NRTIs+PIs treatment regimens.Conclusions In 2023,the prevalence of hyperlipidemia,hypertension,and diabetes among HIV-infected people in Henan Province was relatively high,and the risk of common chronic diseases among those≥40 years old,overweight and obese,and those with a family history of cardiovascular and cerebrovascular diseases was also relatively high.It is recommended to strengthen the prevention and management of common chronic diseases among HIV-infected people.

关 键 词：HIV感染者 高脂血症 高血压 糖尿病 抗病毒治疗 

分 类 号：R512.91[医药卫生—内科学]