阿尔茨海默病神经炎症分子信号通路及相关抗炎药物研究进展  

Progress in study of neuroinflammation molecular signal pathways and anti-inflammatory drugs for Alzheimer's disease

作　　者：张隽[1] 张兰[1] ZHANG Jun;ZHANG Lan(Department of Pharmacy,Xuanwu Hospital Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院药学部,北京100053

出　　处：《临床药物治疗杂志》2025年第2期5-9,共5页Clinical Medication Journal

摘　　要：神经炎症在阿尔茨海默病(AD)中的发病机制引起广泛关注,小胶质细胞、星形胶质细胞及众多炎症因子参与了炎症反应,并涉及多种炎症反应分子信号通路。根据参与AD神经炎症信号通路的炎症因子,可采取作用于靶点的药物治疗。本文就AD部分神经炎症分子信号通路及相关抗炎药物进行综述,为未来研究及临床实践提供参考,以期为AD提供新的治疗方向。The significance of neuroinflammation in Alzheimer's disease(AD)has garnered considerable attention.The inflammatory response involves the participation of microglia,astrocytes,various inflammatory factors,and multiple signaling pathways.Depending on the inflammatory factors involved in the neuroinflammatory signaling pathways of AD,targeted drug therapy may be taken.In this review,we focused on some neuroinflammatory molecular signaling pathways in AD and the related anti-inflammatory medications.This article provides valuable reference for further research direction and clinical practice.

关 键 词：阿尔茨海默病 神经炎症 分子信号通路 抗炎药物 

分 类 号：R971[医药卫生—药品]