心血管疾病治疗药物研究进展  

Progress in Cardiovascular Drug Research

作　　者：杨乔西 蔡军 YANG Qiaoxi;CAI Jun(Department of Hypertension,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung,and Blood Vessel Diseases,Bejing 100013,China)

机构地区：[1]首都医科大学附属北京安贞医院高血压科北京心肺血管疾病研究所,北京100013

出　　处：《临床药物治疗杂志》2025年第1期40-48,共9页Clinical Medication Journal

基　　金：北京研究病房卓越计划(BRWEP2024W012060100)。

摘　　要：心血管疾病已成为中国、美国等国家城乡居民的首位死亡原因。药物是心血管疾病治疗的主要手段,但仍面临靶点单一、部分患者疗效不佳等问题。近年来随着生物信息学、材料科学、干细胞技术等领域的进步以及全球健康策略的引导,心血管各领域在药物新靶标的研究、新种类的开发以及新治疗方式的探索方面取得了一系列重要进展,新型降压药物如盐皮质激素受体拮抗剂、醛固酮合成酶抑制剂等不断涌现;冠心病治疗领域出现了前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂、RNA干扰疗法等创新调脂药物;心力衰竭治疗实现了从传统三联到新四联疗法的演进;肺动脉高压、心律失常等领域也开发了多个新靶点药物。这些创新疗法涵盖了从基因、mRNA到蛋白的多层次调控,整合了小分子药物、生物制剂、中药及细胞治疗等多元手段,为心血管疾病的精准治疗开辟了新途径。Cardiovascular diseases have become the leading cause of death among urban and rural residents in countries such as China and the United States.While pharmacotherapy remains the primary treatment modality for cardiovascular diseases,it stll faces challenges such as single-target limitations and suboptimal efficacy in certain patient populations.Recent advances in bioinformatics,materials science,stem cell technology,and global health strategies have led to significant progress in cardiovascular medications,particularly in the research of novel drug targets,development of new therapeutic agents,and exploration of innovative treatment approaches.Notable developments include the emergence of novel antihypertensive agents such as mineralocorticoid receptor antagonists and aldosterone synthase inhibitors;innovative lipid-lowering therapies for coronary heart disease,including PCSK9 inhibitors and RNA interference therapeutics;evolution of heart failure treatment from traditional triple therapy to new quadruple therapy;and the development of multiple novel target drugs in fields such as pulmonary hypertension and cardiac arrhythmias.These innovative therapies encompass multi-level regulation from genes and mRNA to proteins,integrating diverse therapeutic approaches including small molecule drugs,biologics,traditional Chinese medicine,and cell therapy,thereby pioneering new pathways for precision treatment of cardiovascular diseases.

关 键 词：心血管疾病 药物 研究进展 

分 类 号：R972[医药卫生—药品]