经导管动脉栓塞术治疗膝骨关节炎临床应用及进展  

Clinical application of transcatheter arterial embolization for knee osteoarthritis and its recent advance

作　　者：张昊[1] 靳勇[1] ZHANG Hao;JIN Yong(Department of Interventional Radiology,Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province 215004,China)

机构地区：[1]苏州大学附属第二医院介入治疗科,江苏苏州215004

出　　处：《介入放射学杂志》2025年第2期206-212,共7页Journal of Interventional Radiology

摘　　要：全球范围内,膝骨关节炎(knee osteoarthritis,KOA)正折磨着数百万患者,其不仅带来剧烈的疼痛,还严重降低了患者的生活质量。特别是在65岁以上的膝痛患者群体中,KOA的患病率更是超过50%。近年来,膝动脉栓塞术(genicular artery embolization,GAE)作为一种创新治疗手段,展现出了其在治疗KOA方面的巨大潜力。该技术通过抑制关节内的异常新生血管生成和神经生长,有效改善了患者的疼痛症状和下肢功能障碍。随着临床应用的逐渐推广,GAE为KOA患者提供了一种新的治疗选择。该文综述了GAE在KOA治疗中的应用,包括其治疗原理、手术操作方式、栓塞剂的选择、临床疗效评估以及可能的并发症情况,旨在为该技术在国内的进一步开展和普及提供科学依据和参考。Knee osteoarthritis(KOA)has been afflicting millions of patients around the world.KOA not only brings severe pain to patients,but also seriously reduces the quality of life of patients.In particular,in the population of knee pain patients over 65 years of age,the prevalence of KOA is more than 50%.In recent years,genicular artery embolization(GAE),as an innovative therapeutic means,has shown great potential for the treatment of KOA.Through inhibiting abnormal neoangiogenesis and nerve growth in the diseased joint,GAE can effectively alleviate pain symptoms and improve lower limb dysfunction.With its gradual extension in clinical application,GAE provides a new treatment option for patients with KOA.This article aims to make a comprehensive review about the application of GAE in the treatment of KOA,focusing on its therapeutic principle,operative procedure,selection of embolization agent,evaluation of clinical therapeutic effect,and possible complications,expecting that this technology of GAE can be further developed and popularized in China,and provide scientific basis and reference for clinical practice.

关 键 词：膝动脉栓塞术 膝骨关节炎 疼痛缓解 

分 类 号：R658.3[医药卫生—外科学]