衰老细胞和骨相关疾病关系的研究进展  

Role of senescent cells in bone-related diseases:An updated review

作　　者：唐金茹 李博[2] 刘云坤 侯泽宇 李龙江[1] TANG Jinru;LI Bo;LIU Yunkun;HOU Zeyu;LI Longjiang(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Head and Neck Oncology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院头颈肿瘤外科,四川成都610041 [2]口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院正畸科,四川成都610041 [3]遵义医科大学附属口腔医院牙体牙髓科,贵州遵义563000

出　　处：《口腔医学》2025年第2期134-138,145,共6页Stomatology

基　　金：中国博士后科学基金(2022M712240);四川省自然科学基金(2023NSFSC1519)。

摘　　要：骨相关疾病是一类以异常骨吸收和骨生成为特征的炎症性疾病,疾病种类众多,涉及年龄、炎症、肥胖、遗传、放射线等多种致病因素。近年来,衰老细胞成为年龄相关疾病的重要机制,其在骨相关疾病中的作用也引起了研究人员的注意。衰老细胞逐渐被作为骨相关疾病的治疗靶点,本文就衰老细胞在各类骨相关疾病中的作用机制作一综述,为骨疾病的预防和治疗提供新策略。Bone-related diseases are a group of inflammatory diseases characterized by abnormal bone resorption and formation,with a wide variety of diseases involving age,inflammation,obesity,genetics,radiation,and other pathogenic factors.In recent years,senescent cells have become an important mechanism for age-related diseases,and their role in bone-related diseases has attracted the attention of researchers.Senescent cells are gradually being used as therapeutic targets for bone-related diseases.In this paper,we present a review of the mechanism of senescent cells in various types of bone-related diseases,which will provide new strategies for the prevention and treatment of bone diseases.

关 键 词：衰老细胞 衰老相关分泌表型 骨疾病 

分 类 号：R714.257[医药卫生—妇产科学]