关于银杏酮酯分散片治疗卒中后认知功能障碍的思考和探讨  

Thought and discussion on the treatment of cognitive impairment after stroke with ginkgo ester dispersion tablets

作　　者：堵星玥 陈雪梅 DU Xingyue;CHEN Xuemei

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京医科大学附属江宁医院,江苏南京211000

出　　处：《中医临床研究》2024年第30期92-96,共5页Clinical Journal Of Chinese Medicine

基　　金：江苏省卫健委课题(M2022009);南京市卫生科技发展专项资金资助项目(YKK20203、YKK22216);江宁区科技惠民计划项目(2022092S)。

摘　　要：脑卒中是中国乃至全世界成年人残疾和死亡的主要病因之一,卒中后认知功能障碍(Post-stroke Cognitive Impairment,PSCI)是其最常见的并发症。随着我国人均寿命逐渐延长,人口老龄化日益加重,PSCI的发病率也呈逐年上升趋势,不仅显著影响患者生活质量,同时降低了患者对治疗的依从性,给家庭和社会带来沉重负担。早期干预卒中所致轻度认知障碍,对减少和延缓痴呆的发生有着十分重要的意义。PSCI治疗的主要目的是延缓认知障碍的进一步下降、提高认知水平、改善精神行为症状和提高日常生活能力,这是一个全面的、综合性的治疗,早期干预对于延缓卒中后认知功能损害意义重大。虽然目前常用的静脉溶栓、血管内治疗、抗血小板、抗凝及其他神经保护治疗已广泛用于临床,但仍缺乏有效的治疗药物去修复和逆转急性缺血性卒中导致的神经功能缺损和认知障碍。近年来,中医中药在治疗急性缺血性卒方面已经逐渐受到临床医生的重视。银杏提取物作为传统中药中的瑰宝,在心脑血管疾病治疗方面已引起广泛关注。银杏酮酯分散片应运而生,其作为一种新型的银杏叶提取物,可以通过多途径、多靶点参与卒中后的神经修复及功能改善。文章综述了其药理作用及其在PSCI治疗中的临床研究进展,以期为临床安全有效用药提供参考。Stroke is one of the main causes of disability and death in adults in China and even around the world. Cognitive impairment after stroke is the most common complication. With the gradual extension of life expectancy in China and the increasing aging of the population, the incidence rate of cognitive dysfunction after stroke is also increasing year by year, which not only significantly affects the quality of life of patients, but also reduces the compliance of patients to treatment, bringing a heavy burden to families and society. Early intervention of mild cognitive impairment caused by stroke is very important to reduce and delay the occurrence of dementia. The main purpose of the treatment of cognitive impairment after stroke is to delay the further decline of cognitive impairment, improve cognitive level, relieve mental and behavioral symptoms, and improve daily living ability. This is a comprehensive treatment, and early intervention is of great significance for delaying cognitive impairment after stroke. Although currently commonly used intravenous thrombolysis, endovascular therapy, antiplatelet, anticoagulation and other neuroprotective therapies have been widely applied in the clinical practice, there is still a lack of effective therapeutic drugs to repair and reverse the neurological impairment and cognitive impairment caused by acute ischemic stroke. In recent years, the role of traditional Chinese medicine in the treatment of acute ischemic stroke has gradually attracted the attention of clinicians. As a treasure of traditional Chinese medicine, ginkgo biloba extract has been widely used and gained widespread attention in the treatment of cardiovascular and cerebrovascular diseases. Ginkgo ester dispersion tablets came into being. Ginkgo ester dispersion tablets have emerged as a new type of ginkgo biloba leaf extract, and can participate in neural repair and functional improvement after stroke through multiple pathways and targets. This article reviews its pharmacological effects and clinical researc

关 键 词：银杏酮酯分散片 卒中后认知功能障碍 中药提取物 药理作用 

分 类 号：R25[医药卫生—中医内科学]