基于数据挖掘的中药治疗更年期抑郁症用药规律分析  

An analysis of medication regularity of TCM medicines in the treatment of menopausal depression based on data mining

作　　者：蒋梅 李建珍 陈典谷 王婉灵 魏微 JIANG Mei;LI Jianzhen;CHEN Diangu;WANG Wanling;WEI Wei

机构地区：[1]西南医科大学,四川泸州646000

出　　处：《中医临床研究》2024年第30期102-106,共5页Clinical Journal Of Chinese Medicine

摘　　要：目的:采用数据挖掘技术探析中药治疗更年期抑郁症相关文献,从中得到高频处方和高频中药,用以研究中医药治疗更年期抑郁症的用药特点和组方规律。方法:通过检索万方期刊数据库、中国知网及维普数据库系统中的中文相关文献,选取1990年4月-2023年1月符合中医药治疗更年期抑郁症的临床对比试验文献,对所选文献中的中药处方应用WPS Excel、SPSS Modeler 18.0和SPSS Statistics 27.0分别进行中药频数分析、药性药味归经分析、关联规则分析和系统聚类分析。结果:共检索文献1 050篇,经过严格筛选,纳入75篇文献中的80个中药处方,涉及相关中药151味,使用频率居前6位的中药分别为茯苓、柴胡、当归、白芍、熟地黄和郁金,药物归经主要归肝经、肾经、心经和肺经,药性以温、寒居多,药味以甘、苦居多。关联分析显示山药-山茱萸、茯苓-山药-山茱萸、熟地黄-山药-山茱萸、熟地黄-山药-茯苓的直接关联性最大。聚类分析将中药分为4大类。结论:茯苓为中医药治疗更年期抑郁症的首选药物,常用的关联药对为茯苓-熟地黄、茯苓-山茱萸、茯苓-山药,更年期抑郁症病位在肝、肾、心和脾,可采用补益肝肾和养心健脾的方法治疗。本研究为更年期抑郁的中医临床用药、新处方设计及新药研发提供依据。Objective: Data mining technology was used to analyze modern literature on treating climacteric depression with Chinese medicines, and high-frequency prescriptions and traditional Chinese medicines were obtained from the literature to study the characteristics and medication regularity of TCM treatment of menopausal depression. Methods: By searching the Chinese literature in Wanfang journal database, CNKI and VIP database system, the literature of clinical comparative trial in accordance with traditional Chinese medicine in the treatment of menopausal depression from April 1990 to January 2023 was selected. WPS Excel, SPSS Modeler 18.0 and SPSS Statistics 27.0 were used to perform the frequency, properties, flavor and meridian tropism analyses and association rule analysis and systematic cluster analysis of the selected Chinese medicines. Results: A total of 1 050 studies were searched, and 80 TCM prescriptions in 75 studies were included after strict screening, involving 151 TCM medicinals. The top 6 medicinals in frequency were Fuling(poria tuckahoe), Chaihu(Bupleurum), Danggui(Angelica sinensis), Baishao(Radix Paeoniae alba), Shudihuang(prepared Rehmannia rehmanniae) and Yujin(radix curcumae). The drugs meridian tropism was mainly liver, kidney, heart and lung meridians. The drug properties were mostly warm and cold, and the flavor was mostly sweet and bitter. Correlation analysis showed that the direct correlation of Shanyao(yam)-Shanzhuyu(Cornus officinalis), Fuling-Shanyao-Shanzhuyu, Shudihuang-Shanyao-Shanzhuyu, and Shudihuang-Shanyao-Fuling was the largest. The cluster analysis divided Chinese medicines into 4 categories. Conclusion: Fuling is the first choice of traditional Chinese medicine in the treatment of menopausal depression, and the commonly used associated drug pairs are Fuling-Shudihuang, Fuling-Shanzhuyu, and Fuling-Shanyao. The menopausal depression is located in liver, kidney, heart and spleen, and it can be treated by the methods of tonifying liver and kidney, and invigorating heart and spl

关 键 词：更年期抑郁症 中药 用药规律 数据挖掘 

分 类 号：R277.7[医药卫生—中医学]