雄激素性秃发患者毛发镜特征初步探究  

Trichoscopic features of androgenetic alopecia patients

作　　者：陈曦[1,2] 陈柏孚[1] 李翔倩 张建中 周城[1] Chen Xi;Chen Baifu;Li Xiangqian;Zhang Jianzhong;Zhou Cheng(Department of Dermatology,Peking University People′s Hospital,Beijing 100044,China;Department of Dermatology and Venereology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]北京大学人民医院皮肤科,北京100044 [2]首都医科大学附属北京同仁医院皮肤性病科,北京100730

出　　处：《数字医学与健康》2025年第1期41-48,共8页DIGITAL MEDICINE AND HEALTH

基　　金：国家自然科学基金(82203951,82373504)。

摘　　要：目的:揭示中国雄激素性秃发(AGA)患者不同分型下的毛发受累特征,从而为临床诊疗及相关研究提供科学依据。方法:以北京大学人民医院皮肤科于2019年11月至2020年1月招募的AGA患者和健康人群为受试者,采集其多部位标准化毛发镜图像,使用计算机软件定量测量受试者毛发数量、毛发直径及直径分布、毛囊单位情况,获得受试者相应部位毛发密度、毛发直径、毛囊单位密度等量化数据,并进行统计学分析。结果:研究共纳入AGA患者64例、健康人群29名,其中男性型秃发(MPHL)37例,女性型秃发(FPHL)27例。其中,MPHL型AGA患者额角、顶部、颞部、枕部各部位毛发密度分别为(127.61±19.03)、(134.43±25.88)、(92.01±15.70)、(122.82±16.56)根/cm 2,毛发直径分别为(53.56±8.45)、(53.10±11.37)、(64.34±6.39)、(64.83±7.21)μm,单毛发毛囊单位比例分别为32.57%±11.30%、29.78%±14.56%、21.25%±13.10%、15.69%±9.30%;FPHL型患者相应部位的毛发密度则分别为(112.47±14.37)、(123.25±19.50)、(94.19±26.19)、(114.73±20.98)根/cm 2,毛发直径分别为(54.87±7.00)、(54.74±8.91)、(58.69±10.25)、(62.40±11.34)μm,单毛发毛囊单位比例分别为42.11%±13.84%、32.52%±15.17%、27.35%±14.42%、20.18%±11.03%。MPHL型患者各部位的毛发密度与健康人群的差异无统计学意义,额角、顶部毛发直径显著低于健康人群(P<0.05),顶部的单毛发毛囊单位比例显著低于健康人群(P<0.05)。FPHL型患者顶、枕部毛发密度均显著低于健康人群(P<0.05),额角、顶、颞部毛发直径均显著低于健康人群(P<0.05),且终毛及毳毛比例与健康人群的差异均有统计学意义(P<0.05),四部位单毛发毛囊单位比例亦显著高于健康人群(P<0.05)。在各部位中,MPHL患者毛发受累以额角、顶部为主,FPHL型患者以顶部为主,但各部位均有不同程度受累。MPHL及FPHL的主要受累部位毛发直径均与疾病严重程度密切相关,伴单毛发�ObjectiveTo reveal the characteristics of hair involvement under different subtypes of androgenetic alopecia(AGA)patients in China,so as to provide a scientific basis for clinical diagnosis and treatment as well as related research.MethodsThe subjects of this study were AGA patients and healthy individuals recruited by the Department of Dermatology of Peking University People′s Hospital from November 2019 to January 2020.Multi-area trichoscopy images were analyzed using specialized software to quantitatively assess hair count,hair diameter and diameter distribution,and the number and distribution of hair follicle units.The data of hair density,hair diameter,hair follicle unit density,and single hair follicle unit ratio etc.in frontal angle,vertical,temporal and occipital area were obtained,and statistical analysis was conducted.ResultsA total of 64 patients with AGA and 29 normal subjects were included in this study,including 37 male pattern hair loss(MPHL)patients and 27 female pattern hair loss(FPHL)patients.The hair density in frontal angle,vertex,temporal and occipital of MPHL patients were(127.61±19.03),(134.43±25.88),(92.01±15.70),(122.82±16.56)/cm 2,respectively.The hair diameter were(53.56±8.45),(53.10±11.37),(64.34±6.39),(64.83±7.21)μm,respectively.The density of single hair follicle unit were 32.57%±11.30%,29.78%±14.56%,21.25%±13.10%,15.69%±9.30%,respectively.The hair density of the corresponding parts of FPHL type patients were(112.47±14.37),(123.25±19.50),(94.19±26.19),(114.73±20.98)/cm 2;respectively.The hair diameter were(54.87±7.00),(54.74±8.91),(58.69±10.25),(62.40±11.34)μm,respectively.The ratio of single hair follicle unit 42.11%±13.84%,32.52%±15.17%,27.35%±14.42%,20.18%±11.03%respectively.There was no significant difference in hair density between the MPHL group and normal control.The diameter of hair in the frontal angle and the vertex area of MPHL group was significantly lower(P<0.05),and the ratio of single hair follicle unit in the vertex area was significantly l

关 键 词：雄激素性秃发 毛发镜 脱发 

分 类 号：R75[医药卫生—皮肤病学与性病学]