依诺肝素钠联合拉贝洛尔治疗妊娠期高血压患者的效果  

Effects of Enoxaparin sodium combined with Labetalol in treatment of patients with gestational hypertension

作　　者：胡淑婷 HU Shuting(Department of Obstetrics and Gynecology of Puyang County People’s Hospital,Puyang 457100 Henan,China)

机构地区：[1]濮阳县人民医院妇产科,河南濮阳457100

出　　处：《中国民康医学》2025年第5期70-72,92,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察依诺肝素钠联合拉贝洛尔治疗妊娠期高血压患者的效果。方法:回顾性分析2021年1月至2024年1月该院收治的90例妊娠期高血压患者的临床资料,按照治疗方法不同将其分为对照组和观察组各45例。对照组采用拉贝洛尔治疗,观察组在对照组基础上联合依诺肝素钠治疗。比较两组临床疗效,治疗前后子宫动脉血流参数[阻力指数(RI)、搏动指数(PI)、收缩期峰值流速/舒张期流速(S/D)]、血管内皮指标[可溶性血管内皮生长因子受体(sFlt-1)、胎盘生长因子(PLGF)、sFlt-1/PLGF]、血压(收缩压、舒张压)水平,以及不良母婴结局发生率。结果:观察组治疗优良率为97.78%(44/45),高于对照组的80.00%(36/45),差异有统计学意义(P<0.05);治疗后,两组S/D、PI、RI水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组sFlt-1、sFlt-1/PLGF水平均低于治疗前,且观察组低于对照组,两组PLGF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良母婴结局发生率为4.44%(2/45),低于对照组的17.78%(8/45),差异有统计学意义(P<0.05)。结论:依诺肝素钠联合拉贝洛尔治疗妊娠期高血压患者可提高治疗优良率,改善血管内皮指标水平,以及降低子宫动脉血流参数水平、血压水平和不良母婴结局发生率,效果优于单纯拉贝洛尔治疗。Objective:To observe effects of Enoxaparin sodium combined with Labetalol in treatment of patients with gestational hypertension.Methods:The clinical data of 90 patients with gestational hypertension admitted to this hospital from January 2021 to January 2024were retrospectively analyzed.According to the different treatment methods,they were divided into control group and observation group,45 cases in each group.The control group was treated with Labetalol,while the observation group was treated with Enoxaparin sodium on the basis of that of the control group.The clinical efficacy,the levels of the uterine artery blood flow parameters [resistance index(RI),pulsatility index(PI),systolic peak velocity/diastolic velocity(S/D)],the vascular endothelial indexes [soluble vascular endothelial growth factor receptor(sFlt-1),placental growth factor(PLGF),sFlt-1/PLGF] and the blood pressure(systolic blood pressure,diastolic blood pressure) before and after the treatment,and the incidence of adverse maternal and infant outcomes were compared between the two groups.Results:The excellent and good rate of the observation group was 97.78%(44/45),which was higher than 80.00%(36/45) of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of S/D,PI and RI in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of sFlt-1 and sFlt-1/PLGF in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the PLGF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before

关 键 词：依诺肝素钠 拉贝洛尔 妊娠期高血压 子宫动脉血流参数 血管内皮 血压 母婴结局 

分 类 号：R714.2[医药卫生—妇产科学]