心脉通胶囊联合美托洛尔治疗冠心病心绞痛患者的效果  

Effects of Xinmaitong capsules combined with Metoprolol in treatment of patients with coronary heart disease and angina pectoris

作　　者：阚献俊 张浩 刘政[1] KAN Xianjun;ZHANG Hao;LIU Zheng(Department of Cardiology of Huangchuan County People’s Hospital,Xinyang 465150 Henan,China)

机构地区：[1]潢川县人民医院心内科,河南信阳465150

出　　处：《中国民康医学》2025年第5期96-98,103,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察心脉通胶囊联合美托洛尔治疗冠心病心绞痛患者的效果。方法:选取2022年10月至2023年10月该院收治的95例冠心病心绞痛患者进行前瞻性研究,按照随机数字表法将其分为对照组47例和研究组48例。两组均进行基础治疗,在此基础上,对照组予以美托洛尔治疗,研究组在对照组基础上联合心脉通胶囊治疗,两组均治疗4周。比较两组临床疗效,治疗前后中医证候积分、心功能指标[室间隔厚度(IVST)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]水平、心肌损伤标志物[基质金属蛋白酶-9(MMP-9)、可溶性细胞间黏附分子-1(sICAM-1)]水平,以及不良反应发生率。结果:研究组治疗总有效率为91.67%(44/48),高于对照组的76.60%(36/47),差异有统计学意义(P<0.05);治疗后,两组胸闷心痛、胸胁胀满、心悸等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IVST、LVEDD水平均低于治疗前,且研究组低于对照组,两组LVEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组MMP-9、sICAM-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:心脉通胶囊联合美托洛尔治疗冠心病心绞痛患者可提高治疗总有效率,降低中医证候积分和心肌损伤标志物水平,改善心功能指标水平,效果优于单纯美托洛尔治疗。Objective:To observe effects of Xinmaitong capsules combined with Metoprolol in treatment of patients with coronary heart disease and angina pectoris.Methods:A prospective study was conducted on 95 patients with coronary heart disease and angina pectoris admitted to this hospital from October 2022 to October 2023.According to the random number table method,they were divided into control group(47 cases)and study group(48 cases).Both groups received basic treatment.On this basis,the control group was treated with Metoprolol,while the study group was treated with Xinmaitong capsules on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the TCM syndrome score,the levels of cardiac function indexes [interventricular septal thickness(IVST),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)] levels,myocardial injury markers [matrix metalloproteinase-9(MMP-9),soluble intercellular adhesion molecule-1(sICAM-1)] before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 91.67%(44/48),which was higher than 76.60%(36/47) in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as chest tightness and heartache,chest distension and palpitation in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IVST and LVEDD in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of MMP-9 and sICA

关 键 词：心脉通胶囊 美托洛尔 冠心病 心绞痛 心功能 心肌损伤 中医证候 

分 类 号：R541.4[医药卫生—心血管疾病]