藿朴夏苓汤加减联合瑞巴派特治疗慢性糜烂性胃炎患者的效果  

Effects of Huopu Xialing decoction combined with Rebamipide in treatment of patients with chronic erosive gastritis

作　　者：李艳歌 董齐燕 周莹 LI Yange;DONG Qiyan;ZHOU Ying(Department of Spleen,Stomach,Hepatobiliary of Xinmi Hospital of Traditional Chinese Medicine,Zhengzhou 452300 Henan,China)

机构地区：[1]新密市中医院脾胃肝胆科,河南郑州452300

出　　处：《中国民康医学》2025年第5期114-117,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察藿朴夏苓汤加减联合瑞巴派特治疗慢性糜烂性胃炎患者的效果。方法:回顾性分析2020年1月至2023年9月该院收治的71例慢性糜烂性胃炎患者的临床资料,根据治疗方法不同将其分为观察组(n=37)和对照组(n=34)。对照组给予瑞巴派特治疗,观察组在对照组基础上联合藿朴夏苓汤加减治疗。比较两组临床疗效,治疗前后中医证候积分(胃脘胀痛、纳差、呃逆、便溏)、胃肠激素[胃泌素(GAS)、胆囊收缩素(CCK)、生长抑素(SS)]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.30%(36/37),高于对照组的82.35%(28/34),差异有统计学意义(P<0.05);治疗后,两组胃脘胀痛、纳差、呃逆、便溏等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组SS水平均高于治疗前,且观察组高于对照组,两组GAS、CCK水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:藿朴夏苓汤加减联合瑞巴派特治疗慢性糜烂性胃炎,可提高临床疗效,降低中医证候积分,调节胃肠激素水平,效果优于单纯瑞巴派特治疗。Objective:To observe effects of Huopu Xialing decoction combined with Rebamipide in treatment of patients with chronic erosive gastritis.Methods:The clinical data of 71 patients with chronic erosive gastritis admitted to this hospital from January 2020 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into observation group(n=37) and control group(n=34).The control group was treated with Rebamipide,while the observation group was treated with Huopu Xialing decoction on the basis of that of the control group.The clinical efficacy,the Traditional Chinese Medicine(TCM) syndrome scores(epigastric pain,anorexia,hiccups,loose stools),the gastrointestinal hormones [gastrin(GAS),cholecystokinin(CCK),somatostatin(SS)] levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.30%(36/37),which was higher than 82.35%(28/34) of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as epigastric pain,anorexia,hiccup and loose stool in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of SS in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of GAS and CCK in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified Huopu Xialing decoction combined with Rebamipide in the treatment of chronic erosive gastritis can improve the clinical efficacy,reduce t

关 键 词：瑞巴派特 糜烂性胃炎 胃泌素 藿朴夏苓汤 加减 

分 类 号：R713.3[医药卫生—妇产科学]