不同剂量米非司酮联合炔诺酮治疗围绝经期异常子宫出血患者的效果比较  

Comparison of effects of different doses of Mifepristone combined with Norethisterone in treatment of perimenopausal patients with abnormal uterine bleeding

作　　者：李秋辉 蔡晓环 郑晓惠 LI Qiuhui;CAI Xiaohuan;ZHENG Xiaohui(Department of Gynecology of Xinyang People’s Hospital,Xinyang 464101 Henan,China)

机构地区：[1]信阳市人民医院妇科,河南信阳464101

出　　处：《中国民康医学》2025年第5期149-151,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较不同剂量米非司酮联合炔诺酮治疗围绝经期异常子宫出血患者的效果。方法:回顾性分析2021—2022年该院收治的88例围绝经期异常子宫出血患者的临床资料,根据米非司酮剂量不同将其分为常规剂量组和大剂量组各44例。两组均给予炔诺酮治疗,在此基础上,常规剂量组给予6.25 mg米非司酮进行治疗,大剂量组给予12.5 mg米非司酮进行治疗。比较两组临床疗效,治疗前后性激素指标[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))]水平、子宫内膜厚度,以及不良反应发生率。结果:大剂量组治疗总有效率为86.36%(38/44),高于常规剂量组的68.18%(30/44),差异有统计学意义(P<0.05);治疗3个月后,两组FSH、LH、E_(2)水平均低于治疗前,且大剂量组低于常规剂量组,差异有统计学意义(P<0.05);两组子宫内膜厚度均小于治疗前,且大剂量组小于常规剂量组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:大剂量米非司酮联合炔诺酮治疗围绝经期异常子宫出血患者,可提高临床疗效,调节性激素水平,减小子宫内膜厚度,效果优于常规剂量米非司酮联合炔诺酮治疗。Objective:To compare effects of different doses of Mifepristone combined with Norethisterone in treatment of perimenopausal patients with abnormal uterine bleeding.Methods:The clinical data of 88 patients with perimenopausal abnormal uterine bleeding admitted to this hospital from 2021 to 2022 were retrospectively analyzed.According to the different doses of Mifepristone,they were divided into conventional dose group and high dose group,44 cases in each group.Both groups were treated with Norethisterone.On this basis,the conventional dose group was treated with 6.25 mg Mifepristone,while the high dose group was treated with 12.5 mg Mifepristone.The clinical efficacy,the levels of sex hormone indexes [follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))],the endometrial thickness before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the high dose group was 86.36%(38/44),which was higher than 68.18%(30/44) in the conventional dose group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of FSH,LH and E_(2) in the two groups were lower than those before the treatment,those in the high dose group were lower than those in the conventional dose group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the endometrial thickness of the two groups were smaller than those before the treatment,that in the high dose group was smaller than that in the conventional dose group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:High dose Mifepristone combined with Norethisterone in the treatment of the perimenopausal patients with abnormal uterine bleeding can improve clinical efficacy,regulate the sex hormone levels,and reduce the endometrial thickness.Moreover,it is superior to conventional dose

关 键 词：围绝经期 异常子宫出血 米非司酮 炔诺酮 性激素 子宫内膜厚度 不良反应 

分 类 号：R711[医药卫生—妇产科学]