Keap1-Nrf2通路在炎症疾病中的研究进展  

Research progresses on Keap1-Nrf2 pathway in inflammatory diseases

作　　者：周文艳 胡珊珊 张万年 庄春林 ZHOU Wenyan;HU Shanshan;ZHANG Wannian;ZHUANG Chunlin(School of Pharmacy,Ningxia Medical University,Yinchuan 750004,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]宁夏医科大学药学院,宁夏银川750004 [2]海军军医大学药学系,上海200433

出　　处：《药学实践与服务》2025年第3期97-108,116,共13页Journal of Pharmaceutical Practice and Service

基　　金：国家自然科学基金“优秀青年基金”资助项目(82022065)。

摘　　要：Kelch样环氧氯丙烷相关蛋白-1-核因子e2相关因子2(Keap1-Nrf2)通路已被证实是应对氧化应激的重要防御机制,调控该系统或许能成为众多疾病的有效治疗策略。主要探讨了Keap1-Nrf2通路在炎症疾病中的研究进展,介绍了Keap1-Nrf2通路的基本组成成分及激活机制,阐述了Keap1-Nrf2通路调控炎症与NF-κB通路、HO-1之间的影响、与炎症介质和酶的表达、炎症小体之间的关系。介绍了靶向Keap1-Nrf2通路的天然产物来源抑制剂、小分子抑制剂以及临床进展,探讨了Keap1-Nrf2通路在炎症治疗中的潜在应用价值。The Keap1-Nrf2 pathway has been shown to be an important defense mechanism against oxidative stress,which may be an effective therapeutic strategy for many diseases.The research progresses on Keap1-Nrf2 pathway in inflammatory diseases were mainly reviewed.The basic components and activation mechanism of Keap1-Nrf2 pathway were introduced.The relationship between Keap1-Nrf2 pathway and the crosstalk between NF-κB pathway and HO-1 pathway,the expression of inflammatory mediators and enzymes,and inflammatory bodies were expounded.Natural product-derived inhibitors,small molecule inhibitors targeting Keap1-Nrf2 pathway and their clinical progress were introduced,and the potential application value of Keap1-Nrf2 pathway in the treatment of inflammation was discussed.

关 键 词：KEAP1 NRF2 炎症 作用机制 抑制剂 

分 类 号：R96[医药卫生—药理学]