从“骨健康计划”视角观照中医药防治骨质疏松症的时代价值与新思路  

Era value and new directions of traditional Chinese medicine in preventing and treating osteoporosis from perspective of"bone health program"

作　　者：章轶立 孙传睿 孙凯 许爱丽 申浩 银河[2] 李玲慧[2] 朱立国[2] 魏戌[2] ZHANG Yi-li;SUN Chuan-rui;SUN Kai;XU Ai-li;SHEN Hao;YIN He;LI Ling-hui;ZHU Li-guo;WEI Xu(School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;Wangjing Hospital,China Academy of Chinese Medical Sciences,Bejing 100102,China;Beijing Temple of Heaven Hospital Afiliated to Capital Medical University,Bejing 100050,China)

机构地区：[1]南京中医药大学中西医结合学院,江苏南京210023 [2]中国中医科学院望京医院,北京100102 [3]首都医科大学附属北京天坛医院,北京100050

出　　处：《中国中药杂志》2025年第3期569-574,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金交叉学部“未病”专项项目(T2341023);中国工程院战略研究与咨询重点项目(2024-XZ-61,2024-XZ-61-01,2024-XZ-61-02,2024-XZ-61-03);2022年青年岐黄学者培养项目(国中医药人教函[2022]256号);2022—2024年度中华中医药学会青年人才托举工程项目(CACM-2022-QNRC2-B28)。

摘　　要：顺应推进健康中国建设,提高人民健康水平的总体要求,2024年“骨健康计划”应运而生。其中,深入开展中医药防控体系建设对实施“骨健康计划”具有重要战略意义。该文聚焦影响人民群众“骨健康”的代表性病种骨质疏松症(osteoporosis,OP),认为加速推进中医药防治OP研究有利于提升居民对于OP的知晓率和认识水平,也有益于着眼OP演变规律并提升疾病认识与全程管理水平;有益于给未来中医药防治OP提供整体研究框架,加强中医药防治OP研究的系统性与完整性;同时,有助于探索新的研究范式以及优化现有研究模式,推动中医药防治骨健康相关疾病领域实现创新性突破。在“骨健康计划”整体布局下,未来一段时间内可重点关注OP早期预防,创新OP极早期诊断干预方式;关注疾病及作用机制的靶标网络发现,深刻阐明OP核心发病机制与中医药疗效机制;此外不仅要关注骨骼本身局部病变及临床转归,更要高度重视其伴随的多种代谢疾病发生发展的情况;进一步着眼OP及其并发症领域促进先进交叉学科技术不断融合,建立基于临床应用场景、大数据驱动的研发体系。最终带动中医药在防治OP等骨病领域取得更大进展,不断为丰富深化“骨健康计划”研究内涵注入新动能。Facing the requirements of promoting the healthy China initiative and improving people′s health, the "bone health program" was proposed in 2024. In-depth development of a traditional Chinese medicine(TCM) prevention and control system is of strategic significance to the implementation of the "bone health program". Focusing on osteoporosis(OP), a representative disease affecting people′s bone health, this paper concludes that accelerating the research on the prevention and control of OP by TCM is conducive to enhancing the knowledge and awareness of OP among the public, and it is beneficial to revealing the evolutionary pattern of OP and improving the understanding and management of this disease. Additionally, it can provide an overall framework for and strengthen the systematicity and completeness of the research on the prevention and treatment of OP by TCM. Meanwhile, it can help to explore new research paradigms and optimize the existing research model, so as to promote innovative breakthroughs in the prevention and treatment of bone health-related diseases by TCM. Under the overall layout of the "bone health program", importance should be attached to the early prevention and the innovation of very early diagnosis and intervention of OP. Emphasis should be put on the discovery of the target network of disease and treatment mechanism for revealing the core pathogenesis of OP and the therapeutic mechanism of TCM. In addition to local lesions of the bone and its clinical outcomes, attention should be paid to the development of multiple metabolic complications. The fusion of advanced interdisciplinary technologies should be promoted for OP and its complications, and thus a research and development system based on clinical application scenarios and driven by big data can be built. The measures above will facilitate the progress in the prevention and treatment of OP and other bone diseases by TCM and provide new momentum for enriching and deepening the research connotation of the "bone health program".

关 键 词：骨健康计划 骨质疏松症 中医药 研究思路 

分 类 号：R259[医药卫生—中西医结合]