“中药炮制化学生物学”的提出及研究思路  

Proposal and research idea of"traditional Chinese medicine processing chemical biology"

作　　者：刘蓬蓬[1,2,3,4] 才谦 史辑[1,2,3,4] 许枬 高慧[1,2,3,4] 曾克武 贾天柱[1,2,3,4] LIU Peng-peng;CAI Qian;SHI Ji;XU Nan;GAO Hui;ZENG Ke-wu;JIA Tian-zhu(School of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Bejing 100191,China;Key Laboratory of Processing Technology and Principle,National Administration of Traditional Chinese Medicine,Dalian 116600,China;Technology Innovation Center for Traditional Chinese Medicine Processing of Liaoning Province,Dalian 116600,China;Traditional Chinese Medicine Processing Technology Inheritance Base of the National Administration of Traditional Chinese Medicine,Dalian 116600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]北京大学药学院,天然药物及仿生药物全国重点实验室,北京100191 [3]国家中医药管理局中药炮制工艺原理解析重点研究室,辽宁大连116600 [4]辽宁省中药炮制专业技术创新中心,辽宁大连116600 [5]国家中医药管理局中药炮制技术传承基地,辽宁大连116600

出　　处：《中国中药杂志》2025年第3期833-839,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82003945,81973478,82074013)。

摘　　要：中药炮制是我国独有并极具特色的一项制药技术。利用现代科学手段阐释传统炮制理论及炮制作用的内涵将有利于促进中药炮制的传承与发展、创新与提高,并能够获得更多原创性的中医药科研成果。中药炮制的突破在其原理研究,而炮制原理的解析在于化学成分转化机制和炮制转化成分生物效应机制的研究。该文首次提出了“中药炮制化学生物学”的概念。在中医药理论指导下,以中药炮制转化的活性成分为化学工具,研究其作用靶点及分子调控机制,阐明中药炮制影响机体生物学效应的科学原理。其研究成果亦为发现新活性组分、新活性先导化合物、创制新饮片、研制中药新药提供了新方向。该文详细介绍了中药炮制化学生物学的产生背景、定义、研究内容、研究思路、研究手段和展望,以期为中药炮制原理的解析提供新的研究思路,为中药炮制“四新八化”的实现提供新的途径。Traditional Chinese medicine(TCM)processing is a unique and highly distinctive pharmaceutical technology in China.Utilizing modern scientific methods to elucidate the connotations of traditional processing theory and its effects is expected to facilitate the inheritance,development,innovation,and enhancement of TCM processing,and lead to more original research outcomes in the field of TCM.The breakthrough in TCM processing lies in the study of its underlying principles,and analyzing these principles involves researching the transformation mechanisms of chemical components and the biological effect mechanisms of the transformed components.This paper proposed the concept of"TCM processing chemical biology"(TCMPCB)for the first time.Under the guidance of TCM theory,the active components transformed during TCM processing were used as chemical tools to study their targets and molecular regulatory mechanisms,aiming to clarify the scientific principles by which TCM processing affected biological effects in the organism.The research findings also provided new directions for discovering novel active components,new lead compounds,creating new decoction pieces,and developing new TCM drugs.This paper provided a detailed introduction to the background,definition,research content,research ideas,research methods,and prospects of TCMPCB,with the aim of offering new research perspectives for analyzing the principles of TCM processing and providing new pathways for achieving the"four new and eight transformations"in TCM processing.

关 键 词：中药炮制化学生物学 中药炮制化学 中药炮制学 

分 类 号：R283[医药卫生—中药学]