肺纤维化中Wnt/β-catenin和TGF-β1/Smad信号通路之间的串扰研究  

Crosstalk between Wnt/β-catenin and TGF-β1/Smad signaling pathways in pulmonary fibrosis

作　　者：周云越 陈星彤 杨金彪 杨蕊红 牛雯颖[1] ZHOU Yunyue;CHEN Xintong;YANG Jinbiao;YANG Ruihong;NIU Wenying(Basic Medical College,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《海南医科大学学报》2025年第5期387-392,共6页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(82274405;82074326)。

摘　　要：肺纤维化(pulmonary fibrosis,PF)一种间质性肺疾病的末期表现,其病因尚不完全明确。PF涉及复杂的病理过程,包括炎症反应、氧化应激、内质网应激、细胞衰老、上皮-间充质转化等,目前尚无有效治疗方法,患者确诊后生存期短,死亡率高,严重威胁着人类健康。大量研究表明,Wnt/β-catenin信号通路与TGF-β1/Smad信号通路在PF的发生、发展中均发挥重要了作用。本文就Wnt/β-catenin信号通路与TGF-β1/Smad信号通路在PF中的调控作用,以及二者之间的潜在相互作用和串扰作简要综述,以期为PF的临床防治提供理论支撑。Pulmonary fibrosis(PF)is a late manifestation of interstitial lung disease,and its etiology is not completely clear.PF involves complex pathological processes,including inflammation,oxidative stress,endoplasmic reticulum stress,cell senescence,epithelial-mesenchymal transition,etc.At present,there is no effective treatment for PF.Patients with PF have a short survival time after diagnosis and a high mortality rate,which seriously threatens human health.A large number of studies have shown that Wnt/β-catenin signaling pathway and TGF-β1/Smad signaling pathway play an important role in the development of pulmonary fibrosis.This article briefly reviews the regulatory role of Wnt/β-catenin signaling pathway and TGF-β1/Smad signaling pathway in PF,as well as the potential interaction and crosstalk between them,in order to provide theoretical support for the clinical prevention and treatment of PF.

关 键 词：肺纤维化 TGF-Β1/SMAD信号通路 WNT/Β-CATENIN信号通路 信号串扰 

分 类 号：R563[医药卫生—呼吸系统]