成纤维细胞激活蛋白抑制剂PET/CT显像在骨与关节疾病诊治中的应用研究进展  

Research progress on the application of fibroblast activation protein inhibitor PET/CT imaging in the diagnosis and treatment of bone and joint diseases

作　　者：林学智 张国建[2] Lin Xuezhi;Zhang Guojian(The First Clinical Medical College of Inner Mongolia Medical University,Hohhot 010050,China;Department of Nuclear Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,呼和浩特010050 [2]内蒙古医科大学附属医院核医学科,呼和浩特010050

出　　处：《中华核医学与分子影像杂志》2025年第2期120-124,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：内蒙古自治区高校青年科技英才项目(NJYT22002);内蒙古医科大学致远人才项目(ZY0202037)。

摘　　要：成纤维细胞激活蛋白(FAP)不仅在肿瘤相关成纤维细胞中过度表达,亦可见于骨与关节疾病。随着放射性核素标记FAP抑制剂(FAPI)PET/CT显像应用范围不断扩大,其在骨与关节疾病诊断和疗效评价中也逐渐显示出很好的临床应用潜力。该文就放射性核素标记FAPI PET/CT显像在骨与关节肿瘤、炎性病变、Erdheim-Chester病(ECD)等多种疾病诊治中的研究进展进行综述,旨在更深入探究FAPI特性并拓展其临床应用范围。Fibroblast activation protein(FAP)is overexpressed not only in cancer-associated fibroblasts,but also in bone and joint diseases.With the continuous expansion of the application range of radionuclide labeled FAP inhibitor(FAPI)PET/CT imaging,it has gradually shown a good potential in the clinical diagnosis and efficacy evaluation of bone and joint diseases.This paper reviews the animal and clinical studies of radionuclide-labeled FAPI PET/CT imaging in the diagnosis and treatment of bone and joint diseases like tumors,inflammation,Erdheim-Chester disease(ECD)and so on,aiming to further explore the characteristics of FAPI and expand the scope of clinical application.

关 键 词：骨疾病 关节疾病 成纤维细胞 拮抗剂和抑制剂 正电子发射断层显像术 体层摄影术 X线计算机 发展趋势 

分 类 号：R68[医药卫生—骨科学]