前庭性偏头痛和梅尼埃病患者前庭诱发肌源性电位的对比研究  

A Comparative Study of Vestibule-Induced Myogenic Potential in Patients with Vestibular Migraine and Meniere Disease

作　　者：李春燕[1] 黄远[1] 杨宇[1] 张静[1] 杨晓英[1] 郑丽 LI Chun-yan;HUANG Yuan;YANG Yu;ZHANG Jing;YANG Xiao-ying;ZHENG Li

机构地区：[1]四川省遂宁市中心医院,遂宁629000

出　　处：《中国听力语言康复科学杂志》2025年第2期150-153,共4页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：遂宁市中心医院科研课题“个性化前庭康复治疗对前庭性偏头痛的疗效评估”(2022ypj28)。

摘　　要：目的 比较前庭性偏头痛(vestibular migraine,VM)和梅尼埃病(meniere's disease,MD)患者前庭诱发肌源性电位(vestibular evoked potential,VEMP)的特点,研究VEMP在两种疾病间的区别与联系,为诊断提供依据。方法 纳入VM患者100例和单侧MD患者100例,选取同期健康对照组100例。受试者均进行颈肌前庭诱发电位(cervical vestibular evoked potential,cVEMP)和眼肌前庭诱发电位(ocular vestibular evoked potential,oVEMP)检查,并对其引出率、N1潜伏期、P1潜伏期、P1-N1波间期、振幅做对比分析。结果 对照组cVEMP、oVEMP引出率高于VM组和MD组,VM组高于MD组(P<0.05)。MD组oVEMP的P1潜伏期、N1潜伏期、P1-N1波间期较VM组延长(P<0.05)。VM组和MD组oVEMP振幅均低于对照组(P<0.05)。MD患者oVEMP的P1潜伏期与眩晕残障量表(dizziness handicap inventory,DHI)弱相关。结论VM和MD患者VEMP的检出率均降低。oVEMP的P1潜伏期、N1潜伏期、P1-N1波间延长可作为VM和MD鉴别诊断的观察指标,oVEMP的P1潜伏期会随MD患者DHI评分的增加而延长。Objective The characteristics of vestibuloevoked myogenic potential(VEMP)in patients with vestibular migraine(VM)and Meniere's disease(MD)were compared and analyzed,and the difference and relationship between VEMP in VM and MD were studied to provide basis for the diagnosis of both diseases.Methods 100 patients with VM,100 patients with unilateral MD,and 100 healthy control group were included.Cervical vestibular evoked potential(cVEMP)and ocular vestibular evoked potential(oVEMP)were examined in all subjects,and their elicitation rates,N1 latencies,P1 latencies,P1-N1 intervals and amplitudes were compared.Results The extraction rate of cVEMP and oVEMP in control group was higher than that in VM group and MD group,and that in VM group was higher than that in MD group(P<0.05).The P1 latency,N1 latency and P1-N1 wave interval of oVEMP in MD group were longer than those in VM group(P<0.05).oVEMP amplitude in VM group and MD group was lower than that in control group(P<0.05).Correlation analysis showed that P1 latency of oVEMP in MD patients was weakly correlated with DHI scale.Conclusion The detection rate of VEMP(including cVEMP and oVEMP)in VM and MD patients is reduced.VM mainly showed a decrease in oVEMP amplitude.The P1 latency,N1 latency and P1-N1 interval prolongation of oVEMP can be used as observation indicators for the differential diagnosis of VM and MD.The P1 latency of oVEMP will be prolonged with the increase of DHI score of MD patients.

关 键 词：前庭性偏头痛 梅尼埃病 前庭诱发肌源性电位 

分 类 号：R764.3[医药卫生—耳鼻咽喉科]