延迟经皮冠脉介入治疗对急性心肌梗死的效果分析  

Effect analysis of delayed percutaneous coronary intervention for acute myocardial infarction

作　　者：王怀 WANG Huai(Jingshan People's Hospital,Jingshan 431800,China)

机构地区：[1]京山市人民医院,431800

出　　处：《中国实用医药》2025年第4期6-10,共5页China Practical Medicine

摘　　要：目的分析延迟经皮冠状动脉(冠脉)介入治疗(PCI)对急性心肌梗死的效果。方法纳入急性心肌梗死患者316例为研究对象,按随机数字表法分为对照组和观察组,各158例。对照组采用药物溶栓治疗,观察组在溶栓治疗基础上采用延迟经皮冠状动脉介入治疗。对比两组治疗效果、心功能指标[左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]、心力衰竭(心衰)标志物[N-末端B型利钠肽前体(NT-proBNP)、肌酸激酶同工酶(CK-MB)]、不良心血管事件发生率。结果观察组治疗总有效率为98.10%,远高于对照组的87.97%,差异显著(P<0.05)。治疗前,两组LVEDV、LVESV、LVEDD、LVESD、LVEF比较差异无统学意义(P>0.05);治疗后,两组LVEDV、LVESV、LVEDD、LVESD均较治疗前有所降低,LVEF较治疗前有所升高,且相比于对照组,观察组LVEDV、LVESV、LVEDD、LVESD更低,LVEF更高,差异显著(P<0.05)。治疗前,两组NT-proBNP、CK-MB水平比较差异无统计学意义(P>0.05);治疗后,两组NT-proBNP、CK-MB水平均较治疗前有所降低,且观察组NT-proBNP(150.22±23.85)pg/ml、CK-MB(26.62±8.21)IU/L低于对照组的(240.82±24.98)pg/ml、(39.92±9.47)IU/L,差异显著(P<0.05)。观察组不良心血管事件发生率为3.16%,低于对照组的9.49%,差异显著(P<0.05)。结论延迟经皮冠状动脉介入治疗急性心肌梗死效果显著,能促进患者心功能改善,降低NT-proBNP、CK-MB水平,延缓左心室重构,减少心血管不良事件发生率,对患者预后改善具有积极作用。Objective To analyze the effect of delayed percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods A total of 316 patients with acute myocardial infarction were included in the study.They were divided into a control group and an observation group by random number table method,each with 158 patients.The control group received thrombolysis therapy,and the observation group received delayed percutaneous coronary intervention therapy.Both groups were compared in terms of therapeutic effect,cardiac function index[left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],heart failure marker[N-terminal pro-B-type natriuretic peptide(NT-proBNP),creatine kinase isoenzyme(CK-MB)],and incidence of cardiovascular adverse events.Results The total effective rate of the observation group was 98.10%,which was much higher than 87.97%of the control group,and the difference was significant(P<0.05).Before treatment,there was no statistical significance in comparison of LVEDV,LVESV,LVEDD,LVESD and LVEF between the two groups(P>0.05).After treatment,LVEDV,LVESV,LVEDD and LVESD in both groups were decreased,and LVEF was increased compared with before treatment;compared with the control group,LVEDV,LVESV,LVEDD and LVESD in the observation group were lower and LVEF was higher;the difference was significant(P<0.05).Before treatment,there was no significant difference in the levels of NT-proBNP and CK-MB between the two groups(P>0.05).After treatment,the levels of NT-proBNP and CK-MB in both groups were lower than those before treatment;the observation group had NT-proBNP of(150.22±23.85)pg/ml and CK-MB of(26.62±8.21)IU/L,which were lower than(240.82±24.98)pg/ml and(39.92±9.47)IU/L in the control group;the difference was significant(P<0.05).The incidence of cardiovascular adverse events in the observation group was 3.16%,which was significantly lowe

关 键 词：急性心肌梗死 延迟经皮冠状动脉介入治疗 心功能 心血管不良事件 

分 类 号：R54[医药卫生—心血管疾病]