胃镜下喷洒凝血酶治疗上消化道出血的疗效研究  

Study on efficacy of thrombin spray under gastroscope on the treatment of upper gastrointestinal bleeding

作　　者：魏霞 李蓓蓓 相文会 WEI Xia;LI Bei-bei;XIANG Wen-hui(Department of Gastroenterology,Gaotang County People's Hospital,Liaocheng 252800,China)

机构地区：[1]山东省高唐县人民医院消化内科,252800

出　　处：《中国实用医药》2025年第4期11-15,共5页China Practical Medicine

摘　　要：目的本研究旨在探讨胃镜下喷洒凝血酶治疗上消化道出血的疗效及安全性。方法100例上消化道出血患者,随机分为实验组和对照组,每组50例。对照组患者接受胃镜下喷洒肾上腺素治疗,实验组患者接受胃镜下喷洒凝血酶治疗。比较两组患者的止血效果、输血量、住院时间、不良事件发生率及血清炎性指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)]水平、负面情绪[抑郁自评量表(SDS)和焦虑自评量表(SAS)评分]。结果实验组患者的输血量(214.64±50.31)ml和住院时间(5.53±1.26)d显著少于对照组的(408.12±68.42)ml、(8.52±2.33)d,具有统计学意义(P<0.05)。实验组患者的止血总有效率96.00%显著高于对照组的76.00%,具有统计学意义(P<0.05)。治疗后,实验组患者的CRP(4.14±1.04)mg/L、IL-6(21.54±4.32)pg/ml均低于对照组的(6.06±1.15)mg/L、(30.18±5.26)pg/ml,PGE2(224.73±27.54)pg/ml高于对照组的(182.64±29.14)pg/ml,具有统计学意义(P<0.05)。治疗后,实验组患者的SDS评分(43.34±3.65)分、SAS评分(41.30±4.65)分明显低于对照组的(56.31±3.38)、(55.32±5.41)分,具有统计学意义(P<0.05)。实验组患者的不良事件发生率6.00%低于对照组的24.00%,具有统计学意义(P<0.05)。结论胃镜下喷洒凝血酶治疗上消化道出血具有显著疗效,能够迅速止血,减少输血量,缩短住院时间,还能减轻患者的炎症反应和负面情绪,降低不良事件发生率,促进康复,值得临床推广应用。Objective To explore the efficacy and safety of thrombin spraying under gastroscope on the treatment of upper gastrointestinal bleeding.Methods 100 patients with upper gastrointestinal bleeding were randomly divided into an experimental group and a control group,with 50 patients in each group.The control group received adrenaline spray under gastroscopy,while the experimental group received thrombin spray under gastroscopy.Comparison was made on the hemostatic effect,blood transfusion volume and hospital stay,incidence of adverse events,serum inflammatory markers[C-reactive protein(CRP),interleukin-6(IL-6),prostaglandin E2(PGE2)],negative mood[self-rating depression scale(SDS)and self-rating anxiety scale(SAS)score]between the two groups of patients.Results The blood transfusion volume and hospital stay were(214.64±50.31)ml and(5.53±1.26)d in the experimental group,which were significantly lower than(408.12±68.42)ml and(8.52±2.33)d in the control group,and there was statistical significance(P<0.05).The total hemostatic effective rate of 96.00%in the experimental group was significantly higher than 76.00%in the control group,and there was statistical significance(P<0.05).After treatment,the experimental group had CRP of(4.14±1.04)mg/L and IL-6 of(21.54±4.32)pg/ml,which were lower than(6.06±1.15)mg/L and(30.18±5.26)pg/ml in the control group;the experimental group had higher PGE2 of(224.73±27.54)pg/ml than(182.64±29.14)pg/ml in the control group;there was statistical significance(P<0.05).After treatment,the SDS score and SAS score were(43.34±3.65)and(41.30±4.65)points in the experimental group,which were significantly lower than(56.31±3.38)and(55.32±5.41)points in the control group,and there was statistical significance(P<0.05).The incidence of adverse events in the experimental group was 6.00%,which was lower than 24.00%in the control group,and there was statistical significance(P<0.05).Conclusion Thrombin spraying under gastroscopy has significant therapeutic effects on upper gastrointestinal bleedi

关 键 词：上消化道出血 胃镜 凝血酶 喷洒 疗效 

分 类 号：R47[医药卫生—护理学]