炎症性肠病患者焦虑抑郁相关影响因素分析  

Analysis of related influencing factors of anxiety and depression in patients with inflammatory bowel diseases

作　　者：张雪 蔡星辰 王二嫚[1] 丁金丽 ZHANG Xue;CAI Xing-chen;WANG Er-man(Department of Gastroenterology,Nanjing Jiangning Hospital,Nanjing 211100,China)

机构地区：[1]南京市江宁医院消化内科,211100

出　　处：《中国实用医药》2025年第4期29-33,共5页China Practical Medicine

摘　　要：目的分析炎症性肠病(IBD)患者焦虑抑郁发生率及其影响因素。方法纳入IBD患者142例,其中克罗恩病(CD)患者65例,溃疡性结肠炎(UC)患者77例。根据医院焦虑和抑郁量表(HADS)评分将IBD患者分为焦虑抑郁患者(60例)和非焦虑抑郁患者(82例),比较焦虑抑郁和非焦虑抑郁患者人群的人口学特征、临床特征等方面的差异,通过单因素及多因素分析IBD患者发生焦虑抑郁的影响因素;并针对CD患者和UC患者分别进行单因素及多因素回归分析,研究CD患者和UC患者发生焦虑抑郁的相关因素。结果142例IBD患者有60例(42.3%)发生焦虑抑郁,其中非焦虑抑郁患者女性占比32.9%,无工作占比18.3%,处于疾病活动期占比52.4%,血红蛋白137(128,148)g/L,C反应蛋白1.92(0.62,6.21)mg/L,血沉7(3,15)mm/h。焦虑抑郁患者中女性占比58.3%,无工作占比43.3%,处于疾病活动期占比73.3%,血红蛋白130(118,140)g/L,C反应蛋白5.20(1.24,12.84)mg/L,血沉13(8,20)mm/h。非焦虑抑郁患者与焦虑抑郁患者的性别、工作情况、疾病活动度、血红蛋白、C反应蛋白、血沉比较,差异有统计学意义(P<0.05)。经多因素Logistic回归分析显示,女性、无工作、疾病处于活动期是IBD患者发生焦虑抑郁的独立危险因素(OR=2.670、3.270、5.199,P<0.05)。CD患者焦虑抑郁的患病率为44.6%(29/65),UC患者焦虑抑郁的患病率为40.3%(31/77)。CD患者中非焦虑抑郁患者与焦虑抑郁患者的性别、工作情况、肛周病变、C反应蛋白、血沉比较,差异有统计学意义(P<0.05)。UC患者中非焦虑抑郁患者与焦虑抑郁患者的性别、工作情况、C反应蛋白、血沉比较,差异有统计学意义(P<0.05)。经Logistic回归分析显示,无工作、有肛周病变是CD患者焦虑抑郁的独立危险因素(OR=4.480、5.518,P<0.05),无工作是UC患者焦虑抑郁的独立危险因素(OR=3.300,P<0.05)。结论IBD患者常伴有焦虑抑郁,并且与性别、无业、疾病活动度等密切相�Objective To analyze the incidence of anxiety and depression in patients with inflammatory bowel disease(IBD)and its influencing factors.Methods 142 patients with IBD were selected,including 65 patients with Crohn's disease(CD)and 77 patients with ulcerative colitis(UC).The IBD patients were categorized into anxious depressed patients(60 cases)and non-anxious depressed patients(82 cases)according to the Hospital Anxiety and Depression Scale(HADS)score.The demographic and clinical characteristics of anxious depressed patients and non-anxious depressed patients were compared,and the influencing factors of anxiety and depression in IBD patients were analyzed by univariate and multivariate analysis;univariate and multivariate regression analysis were performed to study the related factors of anxiety and depression in patients with CD and patients with UC.Results Anxiety and depression occurred in 60(42.3%)of 142 IBD patients.Among the non-anxious depressed patients,32.9%were female,18.3%were unemployed,52.4%were in active phase of the disease,hemoglobin was 137(128,148)g/L,C-reactive protein was 1.92(0.62,6.21)mg/L,erythrocyte sedimentation rate was 7(3,15)mm/h;among the anxious depressed patients,58.3%were female,43.3%were unemployed,73.3%were in active phase of the disease,hemoglobin was 130(118,140)g/L,C-reactive protein was 5.20(1.24,12.84)mg/L,and erythrocyte sedimentation rate was 13(8,20)mm/h.There were statistically significant differences in gender,employment status,disease activity,hemoglobin,C-reactive protein and erythrocyte sedimentation rate between anxious depressed patients and non-anxious depressed patients(P<0.05).Multivariate Logistic regression analysis showed that female,unemployed and active phase of the disease were independent risk factors for anxiety and depression in IBD patients(OR=2.670,3.270,5.199;P<0.05).The prevalence of anxiety and depression was 44.6%(29/65)in patients with CD and 40.3%(31/77)in patients with UC.There were statistically significant differences in gender,employment sta

关 键 词：炎症性肠病 焦虑 抑郁 克罗恩病 溃疡性结肠炎 

分 类 号：R47[医药卫生—护理学]