无创间歇正压通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征的疗效分析  

Analysis of the therapeutic effect of non-invasive intermittent positive pressure ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome

作　　者：师娜 SHI Na(Pediatric Department,Xuzhou Medical University Affiliated Hospital,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属医院儿科,221000

出　　处：《中国实用医药》2025年第4期95-98,共4页China Practical Medicine

摘　　要：目的分析无创间歇正压通气(NIPPV)与肺表面活性物质(PS)联合治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法按随机数字表法将60例NRDS患儿分为对照组(采用NIPPV治疗,28例)和观察组(采用NIPPV联合PS治疗,32例)。比较两组患儿疗效、起始无创通气(NIV)失败率、呼吸困难缓解时间、氧疗时间、血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、酸碱度(pH)]及肺相关并发症发生率。结果观察组治疗总有效率96.88%高于对照组的71.43%(P<0.05)。观察组起始NIV失败率3.13%低于对照组的25.00%,呼吸困难缓解时间(17.24±5.42)h、氧疗时间(2.61±1.14)d、住院时间(39.14±7.28)d均短于对照组的(29.71±10.64)h、(3.52±1.39)d、(45.74±11.36)d(P<0.05)。治疗1 h后,观察组PaCO_(2)(41.71±3.15)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(44.01±3.27)mm Hg,pH(7.30±0.08)、PaO_(2)(80.10±6.13)mm Hg高于对照组的(7.26±0.07)、(73.32±5.25)mm Hg(P<0.05)。观察组并发症发生率6.25%低于对照组的28.57%(P<0.05)。结论采用NIPPV与PS联合治疗NRDS患儿能提高疗效,改善血气分析指标,提高氧合效果,减少并发症发生。Objective To analyze the effect of non-invasive intermittent positive pressure ventilation(NIPPV)combined with pulmonary surfactant(PS)in the treatment of neonatal respiratory distress syndrome(NRDS).Methods 60 children with NRDS were divided into control group(NIPPV treatment,28 cases)and observation group(NIPPV combined with PS treatment,32 cases)according to random numerical table.Comparison was made on therapeutic effect,failure rate of initial non-invasive ventilation(NIV),relief time of dyspnea symptoms,duration of oxygen therapy,blood gas analysis index[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),pH]and incidence of pulmonary complications between the two groups.Results The total effective rate of 96.88%in the observation group was higher than 71.43%in the control group(P<0.05).The failure rate of initial NIV in the observation group was 3.13%,which was lower than 25.00%in the control group;in the observation group,the relief time of dyspnea was(17.24±5.42)h,the duration of oxygen therapy was(2.61±1.14)d and the hospitalization time was(39.14±7.28)d,which were shorter than(29.71±10.64)h,(3.52±1.39)d and(45.74±11.36)d in the control group(P<0.05).After 1 h of treatment,the observation group had PaCO_(2) of(41.71±3.15)mm Hg(1 mm Hg=0.133 kPa)than(44.01±3.27)mm Hg in the control group;the observation group had pH of(7.30±0.08)and PaO_(2) of(80.10±6.13)mm Hg,which were higher than(7.26±0.07)and(73.32±5.25)mm Hg in the control group(P<0.05).The complication rate of 6.25%in the observation group was lower than 28.57%in the control group(P<0.05).Conclusion The combination of NIPPV and PS in the treatment of children with NRDS can improve the therapeutic effect,improve the blood gas analysis index,increase the oxygenation effect and reduce the occurrence of complications.

关 键 词：无创间歇正压通气 肺表面活性物质 新生儿呼吸窘迫综合征 

分 类 号：R72[医药卫生—儿科]