小儿肺炎应用氨溴索注射液+头孢孟多酯治疗的临床效果研究  

Study on clinical effect of ambroxol injection plus cefamandole nafate on pediatric pneumonia

作　　者：郑纪华 ZHENG Ji-hua(Department of Pediatrics,Yiyuan County Hospital of Traditional Chinese Medicine,Zibo 256100,China)

机构地区：[1]沂源县中医医院儿科,256100

出　　处：《中国实用医药》2025年第4期99-102,共4页China Practical Medicine

摘　　要：目的研究氨溴索注射液+头孢孟多酯治疗小儿肺炎的效果。方法选取166例小儿肺炎患儿,以随机数字表法分为对照组(83例,头孢孟多酯治疗)和观察组(83例,氨溴索注射液+头孢孟多酯治疗)。比较两组患儿治疗效果、症状改善情况、肺功能指标、血气分析指标、炎症反应指标。结果观察组总有效率高于对照组(χ^(2)=4.9925,P=0.0254<0.05)。观察组患儿咳嗽消退时间(5.11±0.59)d、气促消退时间(4.12±0.65)d、发热消退时间(3.29±0.65)d、肺部啰音消退时间(4.13±1.25)d、住院时间(6.58±1.33)d均短于对照组的(8.20±1.89)、(5.80±1.56)、(4.70±1.56)、(7.66±1.52)、(8.22±1.36)d(t=14.2182、9.0565、7.6010、16.3416、7.8545,P<0.05)。治疗后,两组患儿第1秒用力呼气容积、用力肺活量、呼气峰流速、血氧饱和度均大于治疗前,动脉血二氧化碳分压低于治疗前,且观察组患儿第1秒用力呼气容积(1.88±0.39)L、用力肺活量(3.20±0.23)L、呼气峰流速(188.98±11.56)L/min、血氧饱和度(98.56±2.53)%大于对照组的(1.33±0.35)L、(2.68±0.28)L、(172.65±12.56)L/min、(89.52±3.69)%,动脉血二氧化碳分压(40.26±5.28)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(52.65±6.25)mm Hg(P<0.05)。治疗后,两组患儿C反应蛋白、肿瘤坏死因子-α均低于治疗前,白细胞介素-10高于治疗前,且观察组患儿C反应蛋白(7.65±1.56)mg/L、肿瘤坏死因子-α(2.68±0.66)pg/ml低于对照组的(15.96±4.23)mg/L、(4.58±0.98)pg/ml,白细胞介素-10(15.36±2.58)pg/ml高于对照组的(11.58±2.33)pg/ml(P<0.05)。结论对于小儿肺炎,选用氨溴索注射液+头孢孟多酯治疗的效果更好,临床中应用具有较大意义。Objective To study the effect of ambroxol injection plus cefamandole nafate on pediatric pneumonia.Methods A total of 166 children with pneumonia were selected and divided into control group(83 cases treated with cefamandole nafate)and observation group(83 cases treated with ambroxol injection plus cefamandole nafate)by random number table method.The therapeutic effect,symptom improvement,lung function index,blood gas index and inflammatory response markers were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(χ^(2)=4.9925,P=0.0254<0.05).In the observation group,the time to resolution of cough was(5.11±0.59)d,the time to resolution of dyspnea was(4.12±0.65)d,the time to resolution of fever was(3.29±0.65)d,the time to resolution of pulmonary rales was(4.13±1.25)d,and the hospitalization time was(6.58±1.33)d,which were shorter than(8.20±1.89),(5.80±1.56),(4.70±1.56),(7.66±1.52),and(8.22±1.36)d in the control group(t=14.2182,9.0565,7.6010,16.3416,7.8545;P<0.05).After treatment,the forced expiratory volume in one second,forced vital capacity,peak expiratory flow rate and blood oxygen saturation in both groups were greater than those before treatment,and the arterial partial pressure of carbon dioxide was lower than that before treatment;in the observation group,the forced expiratory volume in one second was(1.88±0.39)L,the forced vital capacity was(3.20±0.23)L,peak expiratory flow rate was(188.98±11.56)L/min and the blood oxygen saturation was(98.56±2.53)%,which were greater than(1.33±0.35)L,(2.68±0.28)L,(172.65±12.56)L/min and(89.52±3.69)%in the control group;the arterial partial pressure of carbon dioxide of(40.26±5.28)mm Hg(1 mm Hg=0.133 kPa)in the observation group was lower than(52.65±6.25)mm Hg in the control group(P<0.05).After treatment,the C-reactive protein and tumor necrosis factor-αin both group were all lower than those before treatment,and the interleukin-10 was higher than that before treatment;the

关 键 词：头孢孟多酯 小儿肺炎 氨溴索注射液 炎症水平 

分 类 号：R72[医药卫生—儿科]