医学防治对HBV携带者子女HBV感染状况的影响研究  

Study on effect of medical prevention and treatment on HBV infection in children of HBV carriers

作　　者：刘继云 LIU Ji-yun(Shanxian County Center for Disease Control and Prevention,Heze 274300,China)

机构地区：[1]单县疾病预防控制中心,274300

出　　处：《中国实用医药》2025年第4期107-109,共3页China Practical Medicine

摘　　要：目的探讨医学防治对乙型肝炎(乙肝)病毒(HBV)携带者子女HBV感染状况的影响。方法60例HBV携带者,根据是否实施医学防治分为对照组(未实施医学防治)和实验组(实施医学防治),各30例。比较两组用药前后的HBV-DNA载量,新生儿HBV感染发生率,分析实验组治疗后的肝损伤发生率。结果用药前,实验组的HBV-DNA载量为(6.04±2.37)×10^(7) IU/ml,对照组为(6.14±2.06)×10^(7) IU/ml;用药1年后实验组的HBV-DNA载量为(2.03±0.24)×10^(7) IU/ml,对照组为(6.16±2.18)×10^(7) IU/ml。用药1年后,实验组的HBV-DNA载量同用药前及对照组用药1年后相比明显下降(P<0.05),而对照组的HBV-DNA载量与用药前比较无差异(P>0.05)。实验组治疗后没有出现重度肝损伤,1例轻度肝损伤和1例中度肝损伤患者经积极治疗后恢复。同对照组(26.67%)相比,实验组新生儿HBV感染发生率(6.67%)较低(P<0.05)。结论医学防治可降低HBV携带者的HBV-DNA载量,对其肝损伤几率小,且能有效减少HBV携带者子女的HBV感染率,临床应给予重视并做好积极应对。Objective To explore the effect of medical prevention and treatment on hepatitis B virus(HBV)infection in children of HBV carriers.Methods 60 HBV carriers were divided into control group(no medical prevention and control)and experimental group(medical prevention and control)according to whether medical prevention and control was implemented,each with 30 cases.The HBV-DNA load and the incidence of neonatal HBV infection before and after medication were compared between the two groups,and the incidence of liver injury after treatment in the experimental group was analyzed.Results Before medication,the HBV-DNA load in the experimental group was(6.04±2.37)×10^(7) IU/ml,and that in the control group was(6.14±2.06)×10^(7) IU/ml;after 1 year of medication,the HBV-DNA load in the experimental group was(2.03±0.24)×10^(7) IU/ml,and that in the control group was(6.16±2.18)×10^(7) IU/ml.After 1 year of medication,the HBV-DNA load of the experimental group was significantly decreased compared with that before medication in this group and that of the control group(P<0.05),while the HBV-DNA load of the control group was not different from that before medication(P>0.05).There was no severe liver injury in the experimental group after medication,and 1 patient with mild liver injury and 1 patient with moderate liver injury recovered after active treatment.Compared with the control group(26.67%),the incidence of HBV infection in the experimental group(6.67%)was lower(P<0.05).Conclusion Medical prevention and treatment can reduce the HBV-DNA load of HBV carriers,reduce the risk of liver injury,and effectively reduce the HBV infection rate in the children of HBV carriers,which should be paid attention to and actively respond to.

关 键 词：医学防治 乙型肝炎病毒携带者 乙型肝炎病毒感染 

分 类 号：R512.62[医药卫生—内科学]