不同性别尖锐湿疣患者HPV分型和病毒载量的差异及与病情和预后的相关性  

Differences in human papillomavirus typing and viral load in patients with condyloma acuminatum of different genders and their correlation with disease and prognosis

作　　者：孙宁[1] 王忠海[1] 黄慧姝 Sun Ning;Wang Zhonghai;Huang Huishu(Department of Dermatology and Venereology,Daqing Fourth Hospital,Daqing 163712,China;Department of Dermatology and Venereology,Acheng District Traditional Chinese Medicine Hospital of Harbin,Harbin 150300,China)

机构地区：[1]大庆市第四医院皮肤性病科,大庆163712 [2]哈尔滨市阿城区中医院皮肤性病科,哈尔滨150300

出　　处：《中国医师杂志》2025年第2期246-251,共6页Journal of Chinese Physician

摘　　要：目的分析男性和女性尖锐湿疣患者间人乳头瘤病毒(HPV)分型和病毒载量的差异,并探讨其与不同性别尖锐湿疣患者病情和预后的相关性。方法选取2020年1月—2022年12月期间大庆市第四医院及哈尔滨市阿城区中医院收治的123例男性和116例女性HPV阳性尖锐湿疣患者为研究对象,对比两组不同性别患者HPV分型和病毒载量的差异,结合临床资料分析HPV分型和病毒载量与尖锐湿疣病情和预后的相关性。结果男性患者低危型HPV的检出率高于女性,高危型HPV的检出率低于女性,差异均有统计学意义(χ^(2)=20.346,P<0.001;χ^(2)=8.880,P=0.003);男性患者HPV感染类型多为低危型单一感染,女性患者多为多重感染(χ^(2)=17.651,P<0.001)。男性患者低危型HPV6、11、81的病毒载量高于女性(均P<0.05);女性患者高危型HPV16、18、52、53、58、66的病毒载量高于男性(均P<0.05);其余各型HPV的病毒载量在男女患者间差异无统计学意义(均P>0.05)。男性和女性高病毒载量患者>10个疣体数量占比,疣体位于尿道、宫颈、肛管等非外生殖器比例和生殖器疱疹发生率显著高于同性别的低病毒载量患者(均P<0.05)。男性和女性高病毒载量患者的总治疗有效率(77.4%、72.5%)显著低于同性别低病毒载量组(94.3%、91.5%)(χ^(2)=7.637,P=0.007;χ^(2)=6.366,P=0.017)。男性患者总复发率由高至低分别为高危型单一感染、多重感染、低危型单一感染,女性患者总复发率由高至低分别为多重感染、高危型单一感染、低危型单一感染,差异均有统计学意义(χ^(2)=13.989,P=0.001;χ^(2)=10.292,P=0.006)。结论男性和女性尖锐湿疣患者HPV分型分布和病毒载量存在差异,男女患者HPV分型及病毒载量与尖锐湿疣的病情及预后具有相关性。ObjectiveTo analyze the difference of human papillomavirus(HPV)typing and viral load between male and female patients with condyloma acuminatum,and to explore the correlation with the disease condition and prognosis of patients with condyloma acuminatum of different genders.MethodsA total of 123 male and 116 female HPV-positive patients with condyloma acuminatum admitted to the Daqing Fourth Hospital and the Acheng District Traditional Chinese Medicine Hospital of Harbin from January 2020 to December 2022 were selected as the study objects,and the differences in HPV typing and viral load between the two groups of patients with different genders were compared.The relationship between HPV typing and viral load and the condition and prognosis of condyloma acuminatum was analyzed.ResultsThe detection rate of low-risk HPV in male patients was higher than that of female patients,and the detection rate of high-risk HPV was lower than that of female patients,with statistical significance(χ^(2)=20.346,P<0.001;χ^(2)=8.880,P=0.003);The HPV infection types were mostly low-risk single infection in male patients and multiple infection in female patients(χ^(2)=17.651,P<0.001).The viral loads of low-risk HPV6,11 and 81 in male patients were higher than those in female patients(all P<0.05).The viral loads of high-risk HPV16,18,52,53,58 and 66 in female patients were higher than those in male patients(all P<0.05).There was no significant difference in viral load of other HPV types between male and female patients(all P>0.05).The proportion of>10 warts in male and female patients with high viral load,the proportion of warts in urethra,cervix,anal canal and other non-external genitalia and the incidence of genital herpes were significantly higher than those of same sex patients with low viral load(all P<0.05).The total treatment response rate of male and female patients with high viral load(77.4%,72.5%)was significantly lower than that of the same sex group with low viral load(94.3%,91.5%)(χ^(2)=7.637,P=0.007;χ^(2)=6.366,P=0.01

关 键 词：尖锐湿疣 人乳头瘤病毒 基因型 病毒载量 

分 类 号：R75[医药卫生—皮肤病学与性病学]