兽用抗生素纳米递送系统促进口服吸收的研究进展  

Research Progress on Veterinary Antibiotic Nano-Delivery Systems to Enhance Oral Absorption

作　　者：吴炅 张晴 冒玉娟[2] 郭浩宇 崔宇彤 陈竣岚 王坤 于生兰[2] 周闻舞 WU Jiong;ZHANG Qing;MAO Yujuan;GUO Haoyu;CUI Yutong;CHEN Junlan;WANG Kun;YU Shenglan;ZHOU Wenwu(School of Pharmacy,China Pharmaceutical University,Nanjing 210000,China;Department of Animal Pharmacy,Jiangsu Agri-animal Husbandry Vocational College,Taizhou 225300,China;National Experimental Teaching Demonstration Center of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京210000 [2]江苏农牧科技职业学院动物药学院,江苏泰州225300 [3]中国药科大学药学国家实验教学示范中心,江苏南京211198

出　　处：《中国兽医杂志》2025年第3期102-109,共8页Chinese Journal of Veterinary Medicine

基　　金：中国药科大学大学生创新创业训练计划项目(202410316179);泰州市科技项目(TN202315);江苏农牧科技职业学院校级科研项目(NSF2022ZR04)。

摘　　要：近年来,抗生素纳米制剂在畜禽养殖中的应用研究取得了显著进展。传统兽药口服给药具有经济、便捷的优势,适用于大规模养殖,但也存在溶解性低、渗透性低、小肠滞留时间短和多重吸收屏障等问题。纳米递送系统通过提高药物的溶解性和渗透性、实现纳米缓释、增加药物跨膜转运和克服口服吸收屏障等方式,显著提升了口服给药的效果。目前主要的纳米递送系统包括纳米晶和纳米乳、脂质体、环糊精包合物及抗菌纳米材料等。这些系统的应用不仅提高了药物的生物利用度,还在降低药物残留和环境污染方面发挥积极作用。本文就纳米递送系统的优势、兽用抗生素纳米递送系统的主要类型和特点进行综述,为兽用抗生素纳米制剂的研发提供思路。In recent years,significant progress has been made in the application of antibiotic nano-formulations in livestock farming.Traditional oral administration of veterinary medicines offers advantages such as cost-effectiveness and convenience,making it suitable for large-scale farming.However,it also faces challenges such as low solubility,poor permeability,short residence time in the small intestine,and multiple absorption barriers.Nano-delivery systems enhance the solubility and permeability of drugs,enable nano-controlled release,increase transmembrane transport,and overcome oral absorption barriers,significantly improving the effectiveness of oral administration.Current primary nano-delivery systems include nanocrystals,nanoemulsions,liposomes,cyclodextrin complexes,and antimicrobial nanomaterials.The use of these systems not only improves the bioavailability of drugs but also plays an active role in reducing drug residues and environmental pollution.This review discusses the advantages of nano-delivery systems,the main types and characteristics of veterinary antibiotic nano-delivery systems,and provides insights for the development of veterinary antibiotic nano-formulations.

关 键 词：兽药口服给药 抗生素 纳米递送系统 畜禽养殖 

分 类 号：R945[医药卫生—微生物与生化药学] S859[医药卫生—药剂学]