基于数据挖掘的过敏性紫癜性肾炎中医证治用药规律分析  

Analysis of Regularity of Traditional Chinese Medicine Syndrome and Medication for Henoch-Schonlein Purpura Nephritis Based on Data Mining

作　　者：陈银霞 王宝蕊[2] 李建省[2] 贾路目草 任耀全[2] 张雯年 康桂兰 Chen Yinxia;Wang Baorui;Li Jiansheng;Jia Lumucao;Ren Yaoquan;Zhang Wennian;Kang Guilan(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《亚太传统医药》2025年第3期167-172,共6页Asia-Pacific Traditional Medicine

基　　金：国家自然科学基金项目(82360884);国家中医药管理局青年岐黄学者支持项目(国中医药人教函〔2020〕218号);甘肃省中医药科研项目(重点课题)(GZKZ-2022-3)。

摘　　要：目的:采用数据挖掘分析过敏性紫癜性肾炎(HSPN)的中医证治用药规律。方法:以中国知网(CNKI)、维普中文期刊服务平台(VIP)、万方数据知识服务平台(Wanfang Data)、中国生物医学文献数据库(CBM)为数据源,根据纳入和排除标准筛选文献并构建数据库,借助Microsoft Office Excel 2016、IBM SPSS Modeler 18.0、IBM SPSS Statistics 26.0软件,对2000年1月1日-2023年12月31日已发表的过敏性紫癜性肾炎中医药治疗的相关文献进行频次统计、关联规则分析和聚类分析。结果:最终纳入文献291篇,涉及证型116种;共695首复方,267味中药;HSPN的证型以血瘀证最多,其次为气阴两虚证、血热妄行证、脾肾亏虚证、阴虚火旺证等;以自拟方治疗为多;高频药物有生地黄、牡丹皮、赤芍、甘草、茯苓等,药物功效频数分析以清热药、补虚药、止血药、利水渗湿药、活血化瘀药为多;常用药对组合为“生地黄-牡丹皮”“牡丹皮-赤芍+生地黄”“生地黄-赤芍+牡丹皮”“黄芪-白术”;药性以寒性药物为主,药味以苦、甘为主,归经以肝、肺、脾、肾为主;聚类分析得到4首新处方。结论:过敏性紫癜性肾炎病机总属本虚标实,本虚以气阴两虚为主,标实以风热、湿热、热毒、血瘀为主;证型多为血瘀证,提示瘀血贯穿疾病始终;治法以益气养阴、清热解毒、凉血散瘀为主;4首新处方分别具有滋肝肾、清虚热,益肾健脾,活血化瘀,清热解毒、凉血止血的功效。Objective:To explore the rule of traditional Chinese medicine syndrome and medication for henoch-schonlein purpura nephritis(HSPN)by using data mining technology.Methods:CNKI,VIP,Wanfang Data and CBM were used as data sources,literature screening and database construction according to inclusion and exclusion criteria,with Microsoft Office Excel 2016,IBM SPSS Modeler 18.0,IBM SPSS Statistics 26.0 software,The frequency statistics,association rule analysis and cluster analysis of Chinese medicine treatment of henoch purpura nephritis published from January 1,2000 to December 31,2023 were carried out.Results:291 literatures were included,involving 116 types of syndrome.A total of 695 compounds,267 traditional Chinese medicines.The most common syndroms of HSPN were blood stasis,followed by Qi and Yin deficiency,blood heat disorder,spleen and kidney deficiency,Yin deficiency and fire exuberance.Most of the patients were treated with self-designed prescription.High-frequency drugs such as Rehmannia rehmanni,peony bark,Radix paeoniae,licorice,poria,etc.the frequency of drug efficacy analysis were mainly heat-clearing drugs,vacuum-tonifying drugs,hemostatic drugs,water-clearing drugs,blood-activating drugs for removing blood stasis.The common drug combinations were“raw rehmand with peony bark”,“peony bark with red peony and raw Rehmand with peony bark”,“raw Rehmand with red peony bark and peony bark”,“Astragalus with Baizhu”.The main drug properties were cold drugs,the main taste was bitter and sweet,and the main channel was liver,lung,spleen and kidney.Four new prescriptions were obtained by cluster analysis.Conclusion:The pathogenesis of HSPN is mainly primary deficiency with excess.The primary deficiency is mainly qi and Yin deficiency,and the standard deficiency is wind-heat,damp-heat,heat toxicity and blood stasis.Most of the syndromes were blood stasis syndromes,suggesting blood stasis throughout the disease.The main therapeutic methods are qi and Yin,heat and detoxification,cooling blood and dispel

关 键 词：过敏性紫癜性肾炎 中医药 数据挖掘 关联规则 聚类分析 

分 类 号：R256.5[医药卫生—中医内科学]