国家专利中药复方治疗心力衰竭的用药规律分析  

Analysis on the Medication Regularity of Traditional Chinese Medicine Compound Patent in Treating Heart Failure

作　　者：芮洁 周亚滨[2] Rui Jie;Zhou Yabin(Graduate College,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Cardiovascular,The First Hospital Affiliated to Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院心血管病科,黑龙江哈尔滨150040

出　　处：《亚太传统医药》2025年第3期173-177,共5页Asia-Pacific Traditional Medicine

基　　金：全国名老中医药专家传承工作室(国中医药人教函〔2022〕75号);黑龙江省本科高校中央支持地方高校改革发展资金(高水平人才项目)(2020GSP06)。

摘　　要：目的:分析国家专利中药复方治疗心力衰竭的组方遣药规律。方法:检索国家专利数据库公布治疗心力衰竭的专利中药复方,运用Office Excel 2019建立数据库,以中医传承辅助平台V2.5、IBM SPSS Modeler 18.0、Cytoscape 3.9.0、IBM SPSS Statistics 26.0进行用药频数及性味归经统计、关联规则分析、复杂网络图构建、聚类分析、熵层次聚类等。结果:纳入专利中药复方共146首,高频药物有黄芪、丹参、茯苓等;功效以补虚类、活血化瘀类、利水渗湿类为主;药性、药味、归经排在首位的分别是温、甘、心;关联分析共获得31对药物组合;聚类分析得出6组药物组合;熵层次聚类分析得出候选处方5首。结论:专利中药复方治疗心力衰竭遵循扶正祛邪、调和阴阳的治则,多选用补阳、益气、利水、活血化瘀、化痰、行气等药物治疗。Objective:To analyze the medication regularity for the treatment of heart failure with the patents of traditional Chinese medicine.Methods:The national patent database was searched to find the compound patents of traditional Chinese medicine for heart failure treatment.Office Excel 2019 was used to establish a database.The traditional Chinese medicine inheritance auxiliary platform V2.5,IBM SPSS Modeler 18.0,Cytoscape 3.9.0,and IBM SPSS Statistics 26.0 were used for statistics of drug frequency and taste,association rule analysis,complex network diagram construction,clustering analysis,and entropy level clustering.Results:A total of 146 Chinese medicine compound patents were included in the treatment of heart failure.High-frequency drugs include Huangqi-Danshen-Fuling etc,the effects were mainly tonifying deficiency,activating blood circulation and removing blood stasis,water seepage and moisture,the first in terms of medicinal properties,medicinal taste and meridians were warm,sweetness and heart,related analysis had been obtained 31 pairs of drug combinations,6 groups of drug combinations were obtained from cluster analysis,5 candidate prescriptions were obtained from entropy-level clustering analysis.Conclusion:The patented compound prescription of traditional Chinese medicine for the treatment of heart failure follows the principle of strengthening the body resistance and eliminating pathogenic factors,regulating its yin and yang,and using drugs such as tonifying yang,benefiting Qi,benefiting water,activating blood and removing blood stasis,removing phlegm,and Qi.

关 键 词：心力衰竭 专利中药复方 数据挖掘 用药规律 

分 类 号：R259[医药卫生—中西医结合]