中药通过Nrf2信号通路治疗甲亢性肝损伤研究进展  

Research Progress of Traditional Chinese Medicine in Treating Hyperthyroidism-Induced Liver Injury Via Nrf2 Signaling Pathway

作　　者：佟雨 高天舒[2] Tong Yu;Gao Tianshu(Liaoning University of Traditional Chinese Medicine,Shenyang 110085,China;The Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110085 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《亚太传统医药》2025年第3期233-238,共6页Asia-Pacific Traditional Medicine

基　　金：辽宁省中医药临床学(专)科能力建设项目(LNZYXZK201902);辽宁省名中医传承工作室建设项目(2022-1);沈阳市临床医学研究项目(沈科发〔2018〕75号)。

摘　　要：随着现代生活节奏的加快,甲状腺功能亢进症的发病率呈逐年上升趋势,其并发症也随之显著增多。在临床上,甲亢引起的肝损伤目前尚未有理想的治疗方法。在治疗甲亢性肝损伤方面,中药因具有多因素、多渠道、多靶点的优势而具备很大的发展潜力。已有研究证明中药可通过调节机体Nrf2信号通路,抑制炎症反应、氧化应激、细胞凋亡等,从而对甲亢性肝损伤发挥治疗作用。探究中医药通过Nrf2信号通路治疗甲亢性肝损伤的研究进展,以期为未来的基础和临床研究提供思路。The incidence of hyperthyroidism is increasing year by year as the acceleration of the pace of modern life,and hyperthyroidism complications are surely to be a significant increase.A better treatment has not yet been clinically of liver injury caused by hyperthyroidism.It is enormous potential of traditional Chinese medicine in the treatment of hyperthyroid liver injury due to its multi-component,multi-pathway,and multi-target features.Liver injury caused by hyperthyroidism can be treated to inhibit inflammatory responses,oxidative stress,and apoptosis by modulating the Nrf2 signaling pathway,which numerous studies have shown.This review explores the research progress of traditional Chinese medicine in the treatment of liver injury,including the inhibition of hepatic peroxidation through the Nrf2 signaling pathway and provides food for thought of future basic and clinical research.

关 键 词：甲亢性肝损伤 中医药 Nrf2信号通路 

分 类 号：R259[医药卫生—中西医结合]