从热毒论治冠状动脉易损斑块  

Treatment of Coronary Artery Vulnerable Plaques from the Perspective of Heat Toxicity

作　　者：张馨月 滑振 丁书文[2] 李运伦[2] ZHANG Xinyue;HUA Zhen;DING Shuwen;LI Yunlun(Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250355,China;Department of Cardiology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院心血管科,山东济南250014

出　　处：《光明中医》2025年第4期692-695,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：国家自然科学基金(No.82274471);国家中医药管理局高水平中医药重点学科建设项目(No.zyyzdxk-2023120);山东省自然科学基金青年项目(No.ZR2021QH219);国家自然科学基金青年项目(No.82104796)。

摘　　要：急性冠脉综合征是冠状动脉粥样硬化性心脏病(以下简称冠心病)中的危急重症,冠状动脉易损斑块破裂是导致急性冠脉综合征的重要机制。因此,如何稳定易损斑块是心血管疾病研究的热点领域。首届全国名中医丁书文教授倡“心系热毒理论”,致力于冠心病的防治。文章在此基础上,提出脏腑功能失调、心肝火旺是形成易损斑块的重要病理基础,火热鸱张、热毒内生是其重要的病理转归,清热解毒、化痰活血、扶正益气是其重要治法,解毒消斑汤是稳定易损斑块的有效复方。Acute coronary syndrome is a critical condition in coronary heart disease,coronary artery vulnerable plaque rupture is an important mechanism leading to acute coronary syndrome,therefore,how to stabilize susceptible plaque is a hot area of cardiovascular direction.Professor Ding Shuwen,a famous traditional Chinese medicine practitioner,put forward the theory of heat and toxicity in the heart system for prevention and treatment of coronary heart disease.This paper proposes that dysfunction of internal organs and fire in the heart and liver are the important pathological basis for the formation of vulnerable plaques and that fire-heat and heat-toxicity are the important pathological regressions.Clearing heat and removing toxins,resolving phlegm and activating blood,and supporting the correctness of the qi are the important treatments and Jiedu Xiaoban decoction is an effective compound formula for stabilizing the vulnerable plaques.

关 键 词：冠状动脉 易损斑块 中医药疗法 热毒 

分 类 号：R259[医药卫生—中西医结合]