四逆汤加减对原发性高血压患者血压波动及RAAS的影响研究  

Study on the Influence of Modified Sini Decoction for Blood Pressure Fluctuation and Raas of Patients with Primary Hypertension

作　　者：赵珏[1] 张雪[1] ZHAO Jue;ZHANG Xue(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;不详)

机构地区：[1]成都中医药大学附属医院,四川成都610075

出　　处：《中外医学研究》2025年第6期44-47,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究四逆汤加减对原发性高血压患者血压波动及肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法:选取2021年10月—2023年12月成都中医药大学附属医院收治的80例原发性高血压患者作为研究对象。根据随机数表法分为对照组和观察组,每组各40例。对照组行常规高血压西医治疗,观察组在对照组的基础上加用四逆汤加减治疗。比较两组的原发性高血压控制效果、治疗前后的高血压相关证候积分、血压波动指标(收缩压变异性指标及舒张压变异性指标)及RAAS指标[血清血管紧张素-Ⅱ(Ang-Ⅱ)、肾素活性(PRA)及醛固酮(ALD)]。结果:观察组的原发性高血压控制总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组的高血压相关证候积分、血压波动指标及RAAS指标比较,差异无统计学意义(P>0.05),治疗1个及2个疗程后观察组的高血压相关证候积分、血压波动指标及RAAS指标均显著低于对照组,差异有统计学意义(P<0.05)。结论:四逆汤加减在原发性高血压患者中的血压控制效果较好,且可显著改善患者的血压波动及RAAS状态。Objective:To investigate the influence of modified Sini decoction for blood pressure fluctuation and renin-angiotensin-aldosterone system(RAAS)of patients with primary hypertension.Method:A total of 80 patients with essential hypertension admitted to the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2021 to December 2023 were studied.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received conventional Western medicine treatment for hypertension,while the observation group was treated with Sini decoction on the basis of the control group.The control effect of essential hypertension,the scores of hypertension-related syndroms before and after treatment,the indexes of blood pressure fluctuation(systolic and diastolic variability)and RAAS[serum angiotensin-Ⅱ(Ang-Ⅱ),renin activity(PRA)and aldosterone(ALD)]were compared between the two groups.Result:The total effective rate of essential hypertension control in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant differences in the comparisoon of the scores of hypertension-related syndrome,blood pressure fluctuation index and RAAS index between the two groups(P>0.05).After 1 and 2 courses of treatment,the scores of hypertension-related syndrome,blood pressure fluctuation index and RAAS index of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:Sini decoction has a good effect on blood pressure control in patients with essential hypertension,and can significantly improve blood pressure fluctuation and RAAS status.

关 键 词：四逆汤加减 原发性高血压 血压波动 肾素—血管紧张素—醛固酮系统 

分 类 号：R259[医药卫生—中西医结合]