不同疝修补术治疗腹股沟疝的效果及对炎症因子和免疫功能的影响  

Efficacy of Different Hernia Repairs in the Treatment of Inguinal Hernia and Their Effects on Inflammatory Factors and Immune Function

作　　者：何云 占正龙 HE Yun;ZHAN Zhenglong(Macheng Hospital of Traditional Chinese Medicine,Macheng 438399,China;不详)

机构地区：[1]麻城市中医医院,湖北麻城438399

出　　处：《中外医学研究》2025年第6期52-55,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究不同疝修补术治疗腹股沟疝的效果及对炎症因子和免疫功能的影响。方法:选取2023年1月—2023年12月麻城市中医医院收治的80例腹股沟疝患者作为研究对象,按随机数表法分为对照组(n=40)和观察组(n=40)。对照组行开放无张力疝修补术,观察组行腹腔镜下无张力疝修补术。比较两组手术情况、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]、免疫功能(CD3^(+)、CD4^(+)、CD8^(+))及术后并发症。结果:观察组手术时间、住院时间、术后自主活动时间短于对照组,差异有统计学意义(P<0.05)。观察组术中出血量、VAS评分、术后并发症总发生率低于对照组,差异有统计学意义(P<0.05)。观察组治疗费用高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CRP、IL-6、IL-1β、CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。观察组CD3^(+)、CD4^(+)高于对照组,差异有统计学意义(P<0.05)。结论:相较于开放无张力疝修补术,腹腔镜下无张力疝修补术产生的创伤更小,术后炎症反应更轻,并可改善免疫功能,减少术后并发症,有利于患者术后康复。Objective:To explore the curative effect of different hernia repair in the treatment of inguinal hernia and its influence on inflammatory factors and immune function.Method:From January 2023 to December 2023,80 patients with inguinal hernia admitted to Macheng Hospital of Traditional Chinese Medicine were selected as subjects.They were randomly divided into control group(n=40)and observation group(n=40).The control group was treated with open tension-free hernia repair,and the observation group was treated with laparoscopic tension-free hernia repair.The surgical conditions,inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-1β(IL-1β)],immune function(CD3^(+),CD4^(+),CD8^(+))and postoperative complications were compared between the two groups.Result:Compared with the control group,the operation time,hospitalization time and postoperative autonomic activity time of the observation group were shorter,the intraoperative blood loss,VAS score and total incidence of postoperative complications were lower,but the cost of treatment is higher,and the difference was statistically significant(P<0.05).After operation,compared with the control group,the levels of CRP,IL-6,IL-1βand CD8^(+)in the observation group were lower,and the levels of CD3^(+) and CD4^(+) were higher,and the difference was statistically significant(P<0.05).Conclusion:Compared with open tension-free hernia repair,laparoscopic tension-free hernia repair produces less trauma,less postoperative inflammation,improves immune function,reduces postoperative complications,and is conducive to postoperative rehabilitation of patients.

关 键 词：腹股沟疝 无张力疝修补术 腹腔镜手术 炎症因子 免疫功能 

分 类 号：R65[医药卫生—外科学]