冠心病介入手术者心血管事件危险因素及与感染指标的相关性探究  

Exploration of the Correlation between Cardiovascular Event Risk Factors and Infection Indicators in Patients Undergoing Coronary Heart Disease Intervention Surgery

作　　者：曾莉君 冯庆智[2] ZENG Lijun;FENG Qingzhi(The First Naval Hospital of the Southern Theater Command of the People's Liberation Army of China,Zhanjiang 524000,China;不详)

机构地区：[1]中国人民解放军南部战区海军第一医院,广东湛江524000 [2]湛江中心人民医院

出　　处：《中外医学研究》2025年第6期92-96,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析冠心病介入手术患者心血管事件发生的危险因素,并探究其发生与常见感染指标的相关性。方法:选取2020年2月—2023年2月中国人民解放军南部战区海军第一医院接收的218例经皮冠状动脉介入(PCI)手术的冠心病患者的作为研究对象,依据是否出现心血管事件(MACE)分为MACE组(75例)和对照组(143例)。分析冠心病PCI手术患者发生MACE的危险因素,并分析其发生与感染指标的相关性。结果:75例冠心病PCI手术患者发生MACE,发生率为20.64%。logistic多因素回归结果提示,高血压病史、心肌梗死病史、糖尿病病史、术前诊断ST段抬高型心肌梗死(STEMI)、超敏C反应蛋白(hs-CRP)≥10 mg/L、肿瘤坏死因子-α(TNF-α)≥15 pg/mL、白细胞介素-6(IL-6)≥20 pg/mL、白细胞介素-10(IL-10)<100 mg/L、中性粒细胞/淋巴细胞≥8是冠心病PCI手术患者围术期心血管事件的危险因素,差异有统计学意义(P<0.05)。hs-CRP、TNF-α、IL-6、IL-10与PCI手术患者围术期心血管事件的发生均存在相关性,差异有统计学意义(P<0.05)。结论:hs-CRP、TNF-α、IL-6、IL-10水平异常是冠心病PCI手术患者发生MACE的危险因素,提示围术期感染与冠心病PCI手术发生MACE存在相关性。Objective:To analyze the risk factors for cardiovascular events in patients undergoing coronary heart disease intervention surgery and explore their correlation with common infection indicators.Method:218 patients with coronary heart disease who completed percutaneous coronary intervention(PCI)in the First Naval Hospital of the Southern Theater Command of the Chinese People's Liberation Army from February 2020 to February 2023 were selected as the study objects.According to the occurrence of cardiovascular events(MACE),They were divided into the MACE group(75 cases)and control group(143 cases).The risk factors of MACE in patients undergoing PCI were analyzed,and the correlation between MACE and infection index was analyzed.Result:MACE occurred in 75 patients with coronary heart disease after PCI,the incidence was 20.64%.logistic multivariate regression results suggest that History of hypertension,myocardial infarction,diabetes,preoperative diagnosis of STEMI,hypersenstive C-reactive protein(hs-CRP)≥10 mg/L,Tumor Necrosis ractor-alpha(TNF-α)≥15 pg/mL,Interleukin-6(IL-6)≥20 pg/mL,Interleukin-10(IL-10)<100 mg/L and neutrophil/lymphocyte≥8 were risk factors for perioperative cardiovascular events in PCI patients,and the difference was statistically significant(P<0.05).hs-CRP,TNF-α,IL-6 and IL-10 were correlated with perioperative cardiovascular events in PCI patients,and the difference was statistically significant(P<0.05).Conclusion:Abnormal levels of hs-CRP,TNF-α,IL-6 and IL-10 are risk factors for MACE in patients undergoing PCI,suggesting that perioperative infection is correlated with MACE in patients undergoing PCI.

关 键 词：冠心病 经皮冠状动脉介入手术 围术期 感染 心血管事件 

分 类 号：R54[医药卫生—心血管疾病]