血府逐瘀汤对不稳定性心绞痛患者中医症状积分、Lp-pla2及血管内皮功能的影响研究  

Study on the Effects of Xuefu Zhuyu Decoction on Traditional Chinese Medicine Symptom Score,Lp-pla2,and Vascular Endothelial Function in Patients with Unstable Angina Pectoris

作　　者：李尚洪 卢磊 LI Shanghong;LU Lei(Xuzhou City Hospital of TCM,Xuzhou 210000,China;不详)

机构地区：[1]徐州市中医院,江苏徐州210000

出　　处：《中外医学研究》2025年第6期100-103,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究血府逐瘀汤对不稳定性心绞痛患者中医症状积分、脂蛋白相关性磷脂酶A2(Lp-pla2)及血管内皮功能的影响。方法:选取2021年4月—2024年2月徐州市中医院收治的86例不稳定性心绞痛患者作为研究对象,按随机数表法分为对照组(n=43)和观察组(n=43)。对照组常规西药治疗,观察组在对照组的基础上给与血府逐瘀汤进行治疗,两组均治疗21 d。比较两组临床疗效,记录两组治疗前后的中医症状积分、血清炎症因子(IFN-γ)、白介素10(IL-10)、肿瘤坏死因子a(TNF-a)、Lp-pla2和血管内皮功能[可溶性血管细胞间黏附分子(sVCAM-1)、一氧化氮(NO)、血管内皮素-1(ET-1)],并对结果进行比较分析。结果:观察组的治疗总效率显著高于对照组,差异有统计学意义(P<0.05);治疗后两组中医证候积分都下降,且观察组的中医证候积分低于对照组,差异有统计学意义(P<0.05);治疗后,两组IFN-γ、TNF-a和Lp-pla2均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组IL-10均升高,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组s VCAM-1和ET-1均降低,观察组低于对照组,差异有统计学意义(P<0.05);两组NO都上升,观察组高于对照组,差异有统计学意义(P<0.05)。结论:使用血府逐瘀汤对不稳定性心绞痛患者进行治疗,能有效降低炎症反应,降低Lp-pla2,改善患者症状和血管内皮功能。Objective:To investigate the effects of Xuefu Zhuyu Tang on traditional Chinese medicine symptom scores,Lp-pla2,and endothelial function in patients with unstable angina pectoris.Method:A total of 86 patients with unstable angina pectoris admitted to Xuzhou City Hospital of TCM from April 2021 to February 2024 were selected as the study objects and divided into control group(n=43)and observation group(n=43)according to random number table method.The control group was treated with conventional western medicine,while the observation group was treated with Xuefu Zhuyu decoction on the basis of the control group.Both groups were treated for 21 days.The clinical efficacy of the two groups was compared.TCM symptom scores,interferon-γ(IFN-γ),interleukin-10(IL-10),tumor necrosis factor-a(TNF-a),Lp-pla2 and vascular endothelial function[soluble vascular cell adhesion molecule(sVCAM-1),nitric oxide(NO),vascular endotheliin-1(ET-1)]of the two groups were recorded before and after treatment.And the results are compared and analyzed.Result:The total treatment efficiency of the observation group was significantly higher than that of the control group,with statistical significance(P<0.05).After treatment,the TCM syndrome score of both groups decreased,and the TCM syndrome score of observation group was lower than that of control group,and the difference was statistically significant(P<0.05).After treatment,IFN-γ,TNF-a and Lp-pla2 in both groups were decreased,and observation group was lower than control group,and the difference was statistically significant(P<0.05).IL-10 was increased in both groups,and observation group was higher than control group,and the difference was statistically significant(P<0.05).After treatment,sVCAM-1 and ET-1 were decreased in both groups,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).NO increased in both groups,and NO in observation group was higher than that in control group,and the difference was statistically significant(P<

关 键 词：血府逐瘀汤 不稳定性心绞痛 中医证候 脂蛋白相关性磷脂酶A2 血管内皮功能 

分 类 号：R259[医药卫生—中西医结合]