补肾化痰调周法联合来曲唑、二甲双胍治疗肥胖型多囊卵巢综合征不孕症的效果分析  

Effect Analysis of Kidney-Tonifyin g and Phle gm-Resolvin g Therapy Combined with Letrozole and Metformin in the Treatment of Infertility in Obese Women with Polycystic Ovary Syndrome

作　　者：顾洁 邱美林 GU Jie;QIU Meilin(Yancheng Hospital of Traditional Chinese Medicine,Yancheng 224001,China;不详)

机构地区：[1]盐城市中医院(南京中医药大学附属盐城中医院),江苏盐城224001 [2]扬州市江都妇幼保健院

出　　处：《中外医学研究》2025年第6期130-134,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察补肾化痰调周方联合来曲唑、二甲双胍治疗肥胖型多囊卵巢综合征(PCOS)不孕症的临床效果。方法:选取2021年1月—2023年1月盐城市中医院门诊收治的100例肥胖型PCOS不孕症患者,作为研究对象采用随机数表法分为对照组和试验组,每组各50例。对照组接受来曲唑和盐酸二甲双胍治疗,试验组在此基础上联合使用补肾化痰调周方。比较两组用药前后体质量指数(BMI)、性激素[黄体生成素(LH)、卵泡刺激(FSH)、睾酮(T)]、糖代谢[空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]、排卵率和妊娠率等指标。结果:治疗后,试验组BMI显著升高,LH、FSH和T酮水平改善,FPG、FINS、HOMA-IR下降,差异有统计学意义(P<0.05)。试验组排卵率和妊娠率均显著高于对照组,差异有统计学意义(P<0.05)。结论:补肾化痰调周方联合来曲唑、二甲双胍治疗肥胖型PCOS不孕症效果显著,能够有效降低患者BMI,改善性激素水平和糖代谢,显著提高排卵率和妊娠率。Objective:To observe the clinical effects of Bushen Huatan Tiaozhou Formula combined with letrozole and metformin in the treatment of infertility in obese patients with polycystic ovary syndrome(PCOS).Method:A total of 100 obese PCOS infertility patients admitted to the outpatient department of Yancheng Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected as the study objects.Random number table method was used to divide the into control group and experimental group,with 50 cases in each group.The control group was treated with letrozole and metformin hydrochloride,and the experimental group was treated with Bushen Huatan Tiaozhou recipe on this basis.Body mass index(BMI),sex hormones[luteinizing hormone(LH),follicle-stimulating(FSH),testosterone(T)],glucose metabolism[fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR)],ovulation rate and pregnancy rate were compared between the two groups before and after treatment.Result:After treatment,BMI was significantly increased,LH,FSH and testosterone were significantly improved,FPG,FINS and HOMA-IR decreased,with statistical significance(P<0.05).Ovulation rate and pregnancy rate of experimental group were significantly higher than those of control group,with statistical significance(P<0.05).Conclusion:Bushen Huatan Tiaozhou recipe combined with letrozole and metformin can effectively reduce BMI of patients,improve sex hormone levels and glucose metabolism,and significantly increase ovulation rate and pregnancy rate.

关 键 词：补肾化痰调周方 来曲唑 二甲双胍 肥胖型多囊卵巢综合症 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]