伊伐布雷定联合依那普利治疗老年慢性心力衰竭的效果及安全性分析  

Safety Analysis of the Combination of Ivafenbredine and Enalapril in the Treatment of Chronic Heart Failure in the Elderly

作　　者：董雯丽 李小琴 刘海[1] DONG Wenli;LI Xiaoqin;LIU Hai(Gansu Province Hospital Rehabilitation Center,Lanzhou 730000,China;不详)

机构地区：[1]甘肃省康复中心医院,甘肃兰州730000 [2]重庆市人民医院

出　　处：《中外医学研究》2025年第6期138-141,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨老年慢性心力衰竭(CHF)患者通过伊伐布雷定联合依那普利治疗的效果及安全性。方法:选取2021年1月—2023年12月甘肃省康复中心医院收治的120例老年CHF患者,按信封随机法分成试验组(60例)和对照组(60例)。对照组施行单一依那普利治疗,试验组施行伊伐布雷定联合依那普利治疗,对比两组疗效、心功能、炎症反应和安全性等。结果:试验组有效合计率95.00%高于对照组81.67%,差异有统计学意义(P<0.05)。治疗8周后,两组左室PES和FS指标升高,左室PED指标、IL-8、Lep与IFN-γ指标降低;且试验组左室PES和FS指标高于对照组,左室PED指标、IL-8、Lep与IFN-γ指标低于对照组,差异有统计学意义(P<0.05)。两组心房颤动、高钾血症和心悸等不良反应合计率比较,差异无统计学意义(P>0.05)。结论:在老年CHF疾病的治疗中,伊伐布雷定联合依那普利治疗的疗效显著,有助于改善其心功能,减轻炎性反应,且不良反应较少。Objective:Exploring the safety of the treatment of elderly patients with chronic heart failure(CHF)with combination therapy for ivafenbredine and enalapril.Method:A total of 120 elderly CHF patients admitted to the Gansu Province Hospital Rehabilitation Center from January 2021 to December 2023 were selected and divided into test group(60 cases)and control group(60 cases)according to envelope random method.The control group was treated with enalapril alone,while the experimental group was treated with ivabradine combined with enalapril.The efficacy,cardiac function,inflammatory response and safety of the two groups were compared.Result:The effective total rate of 95.00%in experimental group was higher than 81.67%in control group,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,left ventricular PES and FS indexes increased,left ventricular PED,IL-8,Lep and IFN-γindexes decreased in both groups.The left ventricular PES and FS indexes in experimental groups were higher than those in control group,and left ventricular PED,IL-8,Lep and IFN-γindexes were lower than those in control group,with statistical significance(P<0.05).There was no significant difference in the total rate of atrial fibrillation,hyperkalemia and palpitation between the two groups(P>0.05).Conclusion:In the treatment of CHF disease in the elderly,ivabradine combined with enalapril has a significant effect,which helps to improve the heart function,reduce the inflammatory response,and has fewer adverse reactions.

关 键 词：慢性心力衰竭 安全性 伊伐布雷定 老年患者 依那普利 

分 类 号：R541.6[医药卫生—心血管疾病]