糖尿病足溃疡血管形成障碍的机制及干预策略  

Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers

作　　者：陶克 曹涛 郝彤 Tao Ke;Cao Tao;Hao Tong(Department of Wound Repair,Center for Wound Repair and Regenerative Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China;Department of Cell Biology,National Center for Translational Science of Molecular Medicine,Air Force Medical University,Xi'an 710032,China;Department of Burns and Cutaneous Surgery,Burn Center of PLA,the First Affiliated Hospital of Air Force Medical University,Xi'an 710032,China)

机构地区：[1]温州医科大学附属第一医院创面修复与再生医学中心创面修复科,温州325015 [2]空军军医大学国家分子医学转化科学中心细胞生物学教研室,西安710032 [3]空军军医大学第一附属医院全军烧伤中心,烧伤与皮肤外科,西安710032

出　　处：《中华烧伤与创面修复杂志》2025年第2期120-126,共7页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金面上项目(82272269)。

摘　　要：神经、血管受损是糖尿病足溃疡(DFU)发生、发展的重要影响因素。包括高血糖、神经营养受损、缺血、缺氧、感染在内的多种因素所致的下肢血管损伤合并微血管形成障碍是DFU创面迁延难愈的重要原因。血管形成是内皮细胞、内皮祖细胞及干细胞等在各类细胞因子及微环境调控下重建微血管网络的病理生理过程,是DFU创面愈合过程中的关键步骤。DFU创面血管形成障碍的机制复杂多样,该文拟从血管形成微环境、神经营养及细胞功能3个方面对DFU微血管损伤机制及干预策略的新进展加以汇总阐述,以期对DFU的治疗提供新的思路。Nerve and vascular damage are important factors affecting the occurrence and development of diabetic foot ulcer(DFU).Lower extremity vascular injury combined with microangiogenesis disorder caused by various factors including hyperglycemia,neurotrophic impairment,ischemia,hypoxia,and infection is an important reason for delayed healing of DFU wound.Angiogenesis is a pathophysiological process in which endothelial cells,endothelial progenitor cells,and stem cells rebuild microvascular network under the regulation of various cytokines and microenvironment,which is a key step in the process of DFU wound healing.The mechanisms of DFU wound angiogenesis disorders are complex and diverse.This article summarizes the new progress of DFU microvascular injury mechanism and intervention strategies from three aspects including angiogenesis microenvironment,neuronutrition,and cell function to provide new ideas for the treatment of DFU.

关 键 词：糖尿病足 新生血管化 病理性 伤口愈合 细胞微环境 周围神经 

分 类 号：R587.2[医药卫生—内分泌]