重组人胶原蛋白生物材料在组织工程领域的应用研究进展  

Research advances on the application of recombinant human collagen biomaterials in the field of tissue engineering

作　　者：柳欢 奥布力阿西木·牙库普 金荣华 张惟 韩春茂[1] 王新刚[1] Liu Huan;Aobuliaximu Yakupu;Jin Ronghua;Zhang Wei;Han Chunmao;Wang Xingang(Department of Burns and Wound Repair,the Second Affiliated Hospital of Zhejiang University College of Medicine,Hangzhou 310009,China;Department of Plastic Surgery,the Second Affiliated Hospital of Zhejiang University College of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院烧伤与创面修复科,杭州310009 [2]浙江大学医学院附属第二医院整形外科,杭州310009

出　　处：《中华烧伤与创面修复杂志》2025年第2期188-194,共7页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2022YFC2403100);国家自然科学基金面上项目(81772069)。

摘　　要：重大创烧伤等引起的大面积组织和器官缺损是临床上常见的问题。重组人胶原蛋白生物材料具有生物相容性良好、可定制化、氨基酸序列稳定、免疫原性低以及可生物降解等诸多优点,被广泛用于组织工程领域,具有广阔的临床应用前景。该文简要总结了重组人胶原蛋白生物材料的设计与制备方式、加工技术及其在组织工程领域的应用情况及最新研究进展。Extensive tissue and organ defects caused by major trauma and burns are common problems in clinical practice.Recombinant human collagen biomaterials,with advantages including impeccable biocompatibility,customization,stable amino acid sequence,low immunogenicity,and inherent biodegradation,have been widely used in the field of tissue engineering and have broad clinical application prospects.This paper briefly summarizes the design and preparation methods,processing techniques of recombinant human collagen biomaterials and their application in the field of tissue engineering,as well as the latest research advances.

关 键 词：生物相容性材料 组织支架 再生 重组蛋白质类 重组人胶原蛋白 

分 类 号：R318.08[医药卫生—生物医学工程]