多西环素联合甲泼尼龙对儿童重症支原体肺炎症状转归及血清炎症相关指标的影响  

Effect of Doxycycline Combined with Methylprednisolone on the Symptom Progression and Serum Inflammation Related Indicators in Children with Severe Mycoplasma Pneumonia

作　　者：胡庆岩 夏群 赵冰 HU Qing-yan;XIA Qun;ZHAO Bing(Department of Pediatrics,First Affiliated Hospital of Bengbu Medical University,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医科大学第一附属医院儿科,安徽蚌埠233004

出　　处：《湖北科技学院学报(医学版)》2025年第2期121-125,共5页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：蚌埠医科大学自然科学基金重点项目(2023byzd085)。

摘　　要：目的探究多西环素与甲泼尼龙联合对重症支原体肺炎患儿症状转归及血清炎症相关指标的影响。方法将2023年3月至2024年4月于我院儿科接受治疗的86例重症支原体肺炎患儿通过随机数字表法分为观察组与对照组各43例。于常规治疗基础上,观察组予以多西环素联合甲泼尼龙,对照组予以阿奇霉素联合甲泼尼龙,均连续治疗7d。比较两组临床疗效、症状改善时间、治疗前后血清炎症相关指标[乳酸脱氢酶(LDH)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)]变化情况、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰流速(PEF)]及不良反应。结果观察组总有效率较对照组高,各症状改善时间较对照组短,组间差异显著(P<0.05);观察组治疗后LDH、IL-6、CRP低于对照组,FEV1、FVC、PEF高于对照组,组间差异显著(P<0.05);两组不良反应发生率无显著差异(P>0.05)。结论儿童重症支原体肺炎采用多西环素联合甲泼尼龙治疗效果确切,可缩短症状改善时间、降低炎症水平、改善肺功能,短期使用相对安全。Objective To investigate the effects of combined treatment with doxycycline and methylprednisolone on symptom progression and serum inflammation related indicators in children with severe mycoplasma pneumonia.Methods 86 children with severe mycoplasma pneumonia who received treatment in the pediatrics department of the First Affiliated Hospital of Bengbu Medical University from March 2023 to April 2024 were randomly divided into an observation group and a control group,with 43 cases in each group,using a random number table method.On the basis of conventional treatment,the observation group was treated with doxycycline combined with methylprednisolone,while the control group was treated with azithromycin combined with methylprednisolone for 7 consecutive days.The clinical efficacy,symptom improvement time,changes in serum inflammation related indicators[lactate dehydrogenase(LDH),interleukin-6(IL-6),C-reactive protein(CRP)]before and after treatment,lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow rate(PEF)],and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the improvement time of each symptom was shorter than that of the control group,with significant differences between the two groups(P<0.05);After treatment,the LDH,IL-6,and CRP levels in the observation group were lower than those in the control group,while the FEV1,FVC,and PEF levels were higher than those in the control group,with significant differences between the two groups(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of doxycycline and methylprednisolone is effective in treating severe mycoplasma pneumonia in children.It can shorten the time for symptom improvement,reduce inflammation levels,improve lung function,and is relatively safe for short-term use.

关 键 词：支原体肺炎 重症 多西环素 甲泼尼龙 阿奇霉素 

分 类 号：R969[医药卫生—药理学]